Tbio CDK20 Cyclin-dependent kinase 20

Protein Summary

Description

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• Q8IZL9
• A2A389
• A2A390
• B4DQX1
• O95137
• Q5EDC4
• Q5VYW1
• Q9BUF4

Gene Name

• CDK20

Ensembl ID

• ENST00000325303
• ENSP00000322343
• ENSG00000156345
• ENST00000336654
• ENSP00000338975
• ENST00000375871
• ENSP00000365031
• ENST00000375883
• ENSP00000365043
• ENST00000605159
• ENSP00000474485

Symbol

• CCRK
• CDCH
• P42
• CCRK
• CDCH
• PNQALRE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
histone modification site profile	0.76
protein domain	0.73
tissue sample	0.72
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 20

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 20

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Ccrk Subfamily / Cyclin-dependent Kinase 20

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.8   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 319   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.8   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0