Tchem CDK18 Cyclin-dependent kinase 18

Protein Summary

Description

May play a role in signal transduction cascades in terminally differentiated cells.

Uniprot Accession IDs

• Q07002
• Q5VXQ2
• Q6V3A2
• Q6V3A3
• Q96F90

Gene Name

• CDK18

Ensembl ID

• ENST00000360066
• ENSP00000353176
• ENSG00000117266
• ENST00000429964
• ENSP00000399082
• ENST00000506784
• ENSP00000423665

Symbol

• PCTAIRE3
• PCTK3
• PCTK3
• PCTAIRE
• PCTAIRE3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
molecular function	0.94
disease perturbation	0.87
gene perturbation	0.8
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 18

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 18

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Taire Subfamily / Cyclin-dependent Kinase 18

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.01   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 175   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.01   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0