Tchem CDK16 Cyclin-dependent kinase 16

Protein Summary

Description

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro). The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• Q00536
• A8K280
• B7Z7C8
• J3KN74
• J3KQP7

Gene Name

• CDK16

Ensembl ID

• ENST00000276052
• ENSP00000276052
• ENSG00000102225
• ENST00000357227
• ENSP00000349762
• ENST00000457458
• ENSP00000405798
• ENST00000518022
• ENSP00000429751

Symbol

• PCTAIRE1
• PCTK1
• PCTK1
• PCTAIRE
• PCTAIRE1
• PCTGAIRE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
molecular function	0.94
transcription factor	0.81
kinase	0.8
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 16

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 16

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Taire Subfamily / Cyclin-dependent Kinase 16

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.79   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.79   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2