Tchem CDK15 Cyclin-dependent kinase 15

Protein Summary

Description

Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.

Uniprot Accession IDs

• Q96Q40
• A8K8R9
• B8ZZX0
• C9J1N8
• C9K003
• F8W6H8
• Q4ZG86
• Q53TV1
• Q6ZMR9
• Q8IUP1

Gene Name

• CDK15

Ensembl ID

• ENST00000260967
• ENSP00000260967
• ENSG00000138395
• ENST00000410091
• ENSP00000386901
• ENST00000434439
• ENSP00000412775
• ENST00000450471
• ENSP00000406472

Symbol

• ALS2CR7
• PFTK2
• PFTK2
• ALS2CR7
• PFTAIRE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
cellular component	0.75
protein domain	0.73
cell type or tissue	0.72
tissue	0.51

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 15

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 15

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Taire Subfamily / Cyclin-dependent Kinase 15

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.11   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0