Tchem CDK14 Cyclin-dependent kinase 14

Protein Summary

Description

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O94921
• A4D1E6
• A6NK51
• A8WFP6
• B4DHG5
• B4DNM2
• Q75N06
• Q75N22
• Q8N764
• Q9H3D7
• Q9UDR0

Gene Name

• CDK14

Ensembl ID

• ENST00000265741
• ENSP00000265741
• ENSG00000058091
• ENST00000380050
• ENSP00000369390
• ENST00000406263
• ENSP00000385034

Symbol

• KIAA0834
• PFTK1
• PFTK1
• PFTAIRE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
PubMedID	0.86
virus perturbation	0.85
transcription factor perturbation	0.84
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 14

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 14

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Taire Subfamily / Cyclin-dependent Kinase 14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.83   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.83   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0