CDK11B
Cyclin-dependent kinase 11B
Protein Summary
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
- ENST00000340677
- ENSP00000464016
- ENSG00000248333
- ENST00000341832
- ENSP00000463048
- ENST00000407249
- ENSP00000464036
- CDC2L1
- CDK11
- PITSLREA
- PK58
- p58
- PK58
- CDK11
- CLK-1
- CDC2L1
- PITSLREA
- p58CLK-1
- CDK11-p46
- CDK11-p58
- p58CDC2L1
- CDK11-p110
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
transcription factor binding site profile | 0.88 | ||
histone modification site profile | 0.84 | ||
transcription factor | 0.8 | ||
hub protein | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.39 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.39 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0