Tchem CDK11A Cyclin-dependent kinase 11A

Protein Summary

Description

Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• Q9UQ88
• O95227
• O95228
• O96012
• Q12821
• Q12853
• Q12854
• Q2TAJ0
• Q5QPR0
• Q5QPR1
• Q5QPR2
• Q9UBC4
• Q9UBI3
• Q9UEI1
• Q9UEI2
• Q9UP53
• Q9UP54
• Q9UP55
• Q9UP56
• Q9UQ86
• Q9UQ87
• Q9UQ89

Gene Name

• CDK11A

Ensembl ID

• ENST00000358779
• ENSP00000351629
• ENSG00000008128
• ENST00000378633
• ENSP00000367900
• ENST00000404249
• ENSP00000384442

Symbol

• CDC2L2
• CDC2L3
• PITSLREB
• CDC2L2
• CDC2L3
• p58GTA
• PITSLRE
• CDK11-p46
• CDK11-p58
• CDK11-p110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
molecular function	0.93
ligand (protein) perturbation	0.83
hub protein	0.71
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 11a

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 11a

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Pitslre Subfamily / Cyclin-dependent Kinase 11a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0