Tchem CDK10 Cyclin-dependent kinase 10

Protein Summary

Description

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Accession IDs

• Q15131
• A8K370
• A8K8I6
• A8MXU6
• B3KQJ3
• B7Z420
• D3DX82
• D3DX83
• Q0VGZ7
• Q15130
• Q6PJC0

Gene Name

• CDK10

Ensembl ID

• ENST00000353379
• ENSP00000338673
• ENSG00000185324
• ENST00000505473
• ENSP00000424415
• ENST00000617879
• ENSP00000484357

Symbol

• ALSAS
• PISSLRE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
kinase perturbation	0.81
histone modification site profile	0.79
protein domain	0.73
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 10

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 10

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Cdk10 Subfamily / Cyclin-dependent Kinase 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.28   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.28   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0