Tbio CDHR1 Cadherin-related family member 1

Protein Summary

Description

Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity). This gene belongs to the cadherin superfamily of calcium-dependent cell adhesion molecules. The encoded protein is a photoreceptor-specific cadherin that plays a role in outer segment disc morphogenesis. Mutations in this gene are associated with inherited retinal dystrophies. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q96JP9
• Q69YZ8
• Q8IXY5

Gene Name

• CDHR1

Ensembl ID

• ENST00000332904
• ENSP00000331063
• ENSG00000148600
• ENST00000623527
• ENSP00000485478

Symbol

• KIAA1775
• PCDH21
• PRCAD
• RP65
• PRCAD
• CORD15
• PCDH21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.67
histone modification site profile	0.61
tissue	0.54
cell line	0.53
transcription factor	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.46   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.46   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0