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Tbio Cadherin-6

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

 Comments

Property Summary

NCBI Gene PubMed Count 25
PubMed Score 58.85
PubTator Score 42.57

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Cachexia 50 0.0 0.0
Disease Target Count P-value
osteosarcoma 7950 2.3e-07
ovarian cancer 8520 3.6e-04
interstitial cystitis 2312 4.0e-04
oligodendroglioma 2850 7.7e-03
urothelial carcinoma 318 1.3e-02
ependymoma 4679 2.3e-02
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Kidney cancer 2613 0.0 0.6
Melanoma 711 0.0 0.8
Skin cancer 469 0.0 0.8
Disease Target Count Z-score Confidence
Narcolepsy 72 0.0 0.8
Rheumatoid arthritis 1191 0.0 1.6
Disease Target Count Z-score Confidence
Renal Cell Carcinoma 214 4.202 2.1

Expression

  Differential Expression (6)

Disease log2 FC p
ependymoma -1.100 2.3e-02
interstitial cystitis 1.300 4.0e-04
oligodendroglioma -1.200 7.7e-03
osteosarcoma 1.363 2.3e-07
ovarian cancer 2.600 3.6e-04
urothelial carcinoma 1.100 1.3e-02

Synonym

Accession P55285 A8K5H5 Q9BWS0
Symbols CAD6
KCAD

Gene

CDH6

  Ortholog (11)

Species Source Disease
Inparanoid OMA
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (16)

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 GO Function (1)

 GO Component (3)

 GO Process (4)

 Compartment GO Term (11)

 MGI Phenotype (1)

 GWAS Trait (2)

 HCA RNA Cell Line (56)

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 CSPA Cell Line (11)

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Pathway (9)

PDB (1)

Gene RIF (4)

AA Sequence 

MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSD      1 - 70
YQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVE     71 - 140
PESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSV    141 - 210
ESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPES    211 - 280
SPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEAS    281 - 350
NPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS    351 - 420
VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAE    421 - 490
FYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHE    491 - 560
MSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTV    561 - 630
VLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLP    631 - 700
RRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDW    701 - 770
GPRFKKLADMYGGVDSDKDS                                                      771 - 790
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Text Mined References (27)

PMID Year Title