| Tbio | Cadherin-6 |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 2.3e-07 |
| ovarian cancer | 8520 | 3.6e-04 |
| interstitial cystitis | 2312 | 4.0e-04 |
| oligodendroglioma | 2850 | 7.7e-03 |
| urothelial carcinoma | 318 | 1.3e-02 |
| ependymoma | 4679 | 2.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Narcolepsy | 72 | 0.0 | 0.8 |
| Rheumatoid arthritis | 1191 | 0.0 | 1.6 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Renal Cell Carcinoma | 214 | 4.202 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| ependymoma | -1.100 | 2.3e-02 |
| interstitial cystitis | 1.300 | 4.0e-04 |
| oligodendroglioma | -1.200 | 7.7e-03 |
| osteosarcoma | 1.363 | 2.3e-07 |
| ovarian cancer | 2.600 | 3.6e-04 |
| urothelial carcinoma | 1.100 | 1.3e-02 |
MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSD 1 - 70 YQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVE 71 - 140 PESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSV 141 - 210 ESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPES 211 - 280 SPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEAS 281 - 350 NPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS 351 - 420 VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAE 421 - 490 FYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHE 491 - 560 MSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTV 561 - 630 VLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLP 631 - 700 RRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDW 701 - 770 GPRFKKLADMYGGVDSDKDS 771 - 790 //
