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Tbio Cadherin-5

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.

This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]

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Property Summary

NCBI Gene PubMed Count 204
PubMed Score 896.78
PubTator Score 619.11

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (6)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Disease Target Count Z-score Confidence
Multiple Sclerosis 540 0.0 2.0

Expression

  Differential Expression (18)

Disease log2 FC p
ductal carcinoma in situ -1.300 7.1e-04
group 4 medulloblastoma -1.700 1.1e-04
interstitial cystitis 1.700 1.1e-04
intraductal papillary-mucinous adenoma (... -1.200 1.6e-03
intraductal papillary-mucinous carcinoma... -1.300 2.0e-03
intraductal papillary-mucinous neoplasm ... -1.300 1.2e-02
invasive ductal carcinoma -1.900 3.7e-04
juvenile dermatomyositis 1.148 7.3e-06
lung adenocarcinoma -2.100 8.7e-18
lung cancer -1.300 5.9e-03
lung carcinoma -2.300 2.5e-13
medulloblastoma, large-cell -1.500 9.8e-05
nephrosclerosis 1.337 1.1e-04
non-small cell lung cancer -2.526 1.8e-22
osteosarcoma -1.857 4.4e-02
psoriasis -1.700 1.0e-03
ulcerative colitis 1.400 1.9e-03
urothelial carcinoma 1.900 1.4e-05

Synonym

Accession P33151 Q4VAI5 Q4VAI6
Symbols 7B4
CD144

Gene

CDH5

  Ortholog (11)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (18)

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 GO Function (5)

 GO Component (9)

 GO Process (8)

 Compartment GO Term (64)

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 MGI Phenotype (15)

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 HCA RNA Cell Line (48)

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 CSPA Cell Line (4)

Pathway (17)

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Protein-protein Interaction (68)

ACAD11   CTNNA1   CTNNA2   PKP4   CEP57   MYO9B   ASPM   MYO1D   CTNNB1   ARVCF   GPAM   POP4   HADHA   ATF6   KEAP1   SGPL1   PTPRU   MYO5A   MYO5C   POLR3A   PKN3   HADHB   SREBF2   LTBP1   SCML1   TMTC3   CTNND1   SARAF   MYO1B   LRFN1   SNRNP200   POM121   MCRS1   TBL2   SBF1   OSBP   ZMYM1   EXOG   POLR1A   KIDINS220   PNPLA6   VANGL2   RYK   PLD1   PLD2   IQCB1   DAG1   WDR75   UTP15   MACO1   ZNHIT2   ST7   TMEM39A   DNAJC1   MICU2   ITFG1   MICU1   RRP1   KCNJ8   PDZD8   RBFA   TIGD5   TSSC4   PIK3CB   TNFSF9   KCNJ11   VTI1B   CAPN15  

Gene RIF (177)

AA Sequence 

MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGK      1 - 70
IKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIK     71 - 140
VHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIIT    141 - 210
ITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSL    211 - 280
FVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS    281 - 350
PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFR    351 - 420
VTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCEN    421 - 490
AVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDN    491 - 560
GMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARA    561 - 630
HGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHG    631 - 700
GPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKML    701 - 770
AELYGSDPREELLY                                                            771 - 784
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Text Mined References (207)

PMID Year Title