| Tbio | Cadherin-5 |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast Neoplasms | 445 | 0.0 | 0.0 |
| Colorectal Neoplasms | 243 | 0.0 | 0.0 |
| Liver Cirrhosis, Biliary | 33 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| No-Reflow Phenomenon | 3 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Alcoholic Intoxication, Chronic | 289 |
| Biliary cirrhosis | 45 |
| Mammary Neoplasms | 425 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.8e-22 |
| lung adenocarcinoma | 2716 | 8.7e-18 |
| lung carcinoma | 2843 | 2.5e-13 |
| juvenile dermatomyositis | 1187 | 7.3e-06 |
| urothelial carcinoma | 318 | 1.4e-05 |
| medulloblastoma, large-cell | 6241 | 9.8e-05 |
| interstitial cystitis | 2312 | 1.1e-04 |
| group 4 medulloblastoma | 1855 | 1.1e-04 |
| nephrosclerosis | 333 | 1.1e-04 |
| invasive ductal carcinoma | 2951 | 3.7e-04 |
| ductal carcinoma in situ | 1745 | 7.1e-04 |
| psoriasis | 6694 | 1.0e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.6e-03 |
| ulcerative colitis | 1819 | 1.9e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.0e-03 |
| lung cancer | 4740 | 5.9e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.2e-02 |
| osteosarcoma | 7950 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 540 | 0.0 | 2.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Vascular disease | 319 | 4.829 | 2.4 |
| Cancer | 2499 | 4.403 | 2.2 |
| Diabetic retinopathy | 56 | 3.813 | 1.9 |
| Ovarian hyperstimulation syndrome | 19 | 3.588 | 1.8 |
| Respiratory Failure | 104 | 3.23 | 1.6 |
| Paraplegia | 74 | 3.111 | 1.6 |
| diabetes mellitus | 1728 | 3.013 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| ductal carcinoma in situ | -1.300 | 7.1e-04 |
| group 4 medulloblastoma | -1.700 | 1.1e-04 |
| interstitial cystitis | 1.700 | 1.1e-04 |
| intraductal papillary-mucinous adenoma (... | -1.200 | 1.6e-03 |
| intraductal papillary-mucinous carcinoma... | -1.300 | 2.0e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.300 | 1.2e-02 |
| invasive ductal carcinoma | -1.900 | 3.7e-04 |
| juvenile dermatomyositis | 1.148 | 7.3e-06 |
| lung adenocarcinoma | -2.100 | 8.7e-18 |
| lung cancer | -1.300 | 5.9e-03 |
| lung carcinoma | -2.300 | 2.5e-13 |
| medulloblastoma, large-cell | -1.500 | 9.8e-05 |
| nephrosclerosis | 1.337 | 1.1e-04 |
| non-small cell lung cancer | -2.526 | 1.8e-22 |
| osteosarcoma | -1.857 | 4.4e-02 |
| psoriasis | -1.700 | 1.0e-03 |
| ulcerative colitis | 1.400 | 1.9e-03 |
| urothelial carcinoma | 1.900 | 1.4e-05 |
ACAD11
CTNNA1
CTNNA2
PKP4
CEP57
MYO9B
ASPM
MYO1D
CTNNB1
ARVCF
GPAM
POP4
HADHA
ATF6
KEAP1
SGPL1
PTPRU
MYO5A
MYO5C
POLR3A
PKN3
HADHB
SREBF2
LTBP1
SCML1
TMTC3
CTNND1
SARAF
MYO1B
LRFN1
SNRNP200
POM121
MCRS1
TBL2
SBF1
OSBP
ZMYM1
EXOG
POLR1A
KIDINS220
PNPLA6
VANGL2
RYK
PLD1
PLD2
IQCB1
DAG1
WDR75
UTP15
MACO1
ZNHIT2
ST7
TMEM39A
DNAJC1
MICU2
ITFG1
MICU1
RRP1
KCNJ8
PDZD8
RBFA
TIGD5
TSSC4
PIK3CB
TNFSF9
KCNJ11
VTI1B
CAPN15
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGK 1 - 70 IKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIK 71 - 140 VHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIIT 141 - 210 ITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSL 211 - 280 FVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS 281 - 350 PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFR 351 - 420 VTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCEN 421 - 490 AVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDN 491 - 560 GMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARA 561 - 630 HGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHG 631 - 700 GPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKML 701 - 770 AELYGSDPREELLY 771 - 784 //
