Tbio | Cadherin-15 |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Mental Retardation, Autosomal Dominant 3 | 1 | 0.0 | 0.0 |
Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
Disease | Target Count | P-value |
---|---|---|
lung adenocarcinoma | 2716 | 2.6e-04 |
atypical teratoid / rhabdoid tumor | 5112 | 3.0e-04 |
glioblastoma | 5792 | 1.1e-03 |
adult high grade glioma | 3801 | 2.7e-03 |
diabetes mellitus | 1728 | 1.1e-02 |
osteosarcoma | 7950 | 1.7e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Hypotrichosis | 47 | 4.599 | 2.3 |
Autosomal recessive nonsyndromic deafness 89 | 6 | 4.183 | 2.1 |
Blindness | 88 | 3.358 | 1.7 |
Familial hemophagocytic lymphohistiocytosis 2 | 15 | 3.262 | 1.6 |
KBG syndrome | 9 | 3.114 | 1.6 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | -1.600 | 2.7e-03 |
atypical teratoid / rhabdoid tumor | -1.400 | 3.0e-04 |
diabetes mellitus | -1.200 | 1.1e-02 |
glioblastoma | -1.500 | 1.1e-03 |
lung adenocarcinoma | 1.300 | 2.6e-04 |
osteosarcoma | 1.379 | 1.7e-02 |
Accession | P55291 |
Symbols |
CDH3 CDHM MCAD MRD3 CDH14 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA |
MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLVQIKS 1 - 70 DKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEI 71 - 140 VVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGE 141 - 210 IRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGR 211 - 280 LEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQA 281 - 350 AALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPED 351 - 420 WLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGS 421 - 490 LCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLL 491 - 560 LRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARF 561 - 630 WKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQP 631 - 700 PRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWG 701 - 770 PRFARLADMYGHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA 771 - 814 //