Tbio CDH11 Cadherin-11

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55287
• A8K5D6
• A8MZC8
• B7WP28
• Q15065
• Q15066
• Q9UQ93
• Q9UQ94

Gene Name

• CDH11

Ensembl ID

• ENST00000268603
• ENSP00000268603
• ENSG00000140937
• ENST00000394156
• ENSP00000377711

Symbol

• OB
• ESWS
• CAD11
• CDHOB
• OSF-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
gene perturbation	0.92
transcription factor perturbation	0.88
disease	0.79
phenotype	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.54   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 779   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 278.54   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 779   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0