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Tbio
CDCA3
Cell division cycle-associated protein 3

Protein Summary
Description
F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000535406
  • ENSP00000446339
  • ENSG00000111665
  • ENST00000538862
  • ENSP00000442068

Symbol
  • C8
  • GRCC8
  • TOME1
  • GRCC8
  • TOME-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
kinase perturbation
0.84
PubMedID
0.82
transcription factor perturbation
0.74
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.98   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.98   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0