CDC42BPG
Serine/threonine-protein kinase MRCK gamma
Protein Summary
May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
- ENST00000342711
- ENSP00000345133
- ENSG00000171219
- DMPK2
- DMPK2
- MRCKG
- HSMDPKIN
- KAPPA-200
- MRCKgamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.95 | ||
metabolite | 0.82 | ||
interacting protein | 0.62 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.97 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 31 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.97 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 31 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0