| Tbio | Dual specificity protein phosphatase CDC14A |
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis.
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| DEAFNESS, AUTOSOMAL RECESSIVE 105 | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 3.0e-14 |
| ulcerative colitis | 1819 | 9.8e-10 |
| osteosarcoma | 7950 | 7.0e-09 |
| ovarian cancer | 8520 | 3.8e-07 |
| Breast cancer | 3578 | 1.9e-06 |
| malignant mesothelioma | 3232 | 1.6e-05 |
| medulloblastoma, large-cell | 6241 | 9.4e-05 |
| colon cancer | 1478 | 3.9e-04 |
| gastric cancer | 459 | 4.3e-04 |
| psoriasis | 6694 | 5.0e-04 |
| Endometriosis | 540 | 8.3e-03 |
| lung cancer | 4740 | 2.8e-02 |
| chronic rhinosinusitis | 512 | 3.3e-02 |
| Rheumatoid arthritis | 1191 | 4.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Nonsyndromic deafness | 142 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| cartilage-hair hypoplasia | 7 | 3.275 | 1.6 |
| Neuronal ceroid lipofuscinosis 2 | 17 | 3.239 | 1.6 |
| MASA syndrome | 8 | 3.118 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | -1.600 | 1.9e-06 |
| chronic rhinosinusitis | -1.397 | 3.3e-02 |
| colon cancer | -1.500 | 3.9e-04 |
| Endometriosis | -1.327 | 8.3e-03 |
| gastric cancer | 1.300 | 4.3e-04 |
| lung adenocarcinoma | -1.100 | 3.0e-14 |
| lung cancer | -1.300 | 2.8e-02 |
| malignant mesothelioma | -1.700 | 1.6e-05 |
| medulloblastoma, large-cell | 1.300 | 9.4e-05 |
| osteosarcoma | -3.096 | 7.0e-09 |
| ovarian cancer | -1.500 | 3.8e-07 |
| psoriasis | -1.700 | 5.0e-04 |
| Rheumatoid arthritis | 1.200 | 4.1e-02 |
| ulcerative colitis | -2.500 | 9.8e-10 |
MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKK 1 - 70 LKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYN 71 - 140 LTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPE 141 - 210 AYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKA 211 - 280 GLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEG 281 - 350 SINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDD 351 - 420 TKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNA 421 - 490 ATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEE 491 - 560 HTTILRPSYTGLSSSSARFLSRSIPSLQSEYVHY 561 - 594 //
