| Tbio | Codanin-1 |
May act as a negative regulator of ASF1 in chromatin assembly.
This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]
This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009]
Comments
| Disease | Target Count |
|---|---|
| Congenital dyserythropoietic anemia, type I | 1 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7933 | 1.4e-06 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Congenital dyserythropoietic anemia | 17 | 0.0 | 4.0 |
| Congenital hemolytic anemia | 31 | 0.0 | 4.0 |
| Disease | Target Count |
|---|---|
| Anemia, Congenital Dyserythropoietic, Type Ia | 1 |
| Disease | Target Count |
|---|---|
| Anemia, congenital dyserythropoietic, 1A | 1 |
| PMID | Text | |
|---|---|---|
| 24196372 | The proband with congenital dyserythropoietic anemia Iota in the first family was a compound heterozygote of CDAN1 with mutation IVS-12+2T>C and c. 3389C>T. | |
| 23716552 | The missense substitution in CDAN1, C15ORF41, encodes a novel restriction endonuclease in congenital dyserythropoietic anemia type I. | |
| 22407294 | The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. | |
| 21364188 | A link between mutant codanin-1 and the aberrant localization of HP1 alpha is supported by the finding that codanin-1 can be coimmunoprecipitated by anti-HP1 alpha antibodies erythroblasts from patients with congenital dyserythropoietic anemia type 1. | |
| 19336738 | Data suggest that codanin-1 is a cell cycle-regulated protein active in the S phase. | |
| 18575862 | Congenital dyserythropoietic anemia I (CDA I) is a well-defined entity within the heterogeneous group of the CDAN1 family; here it is associated with mutations in a Chinese family. | |
| 18081704 | This second case of retinal angioid streaks in CDA I reports a patient homozygous for the Arg1042Trp mutation in codanin-1. | |
| 16767397 | codanin-1 may play a role in the development of the skeleton. | |
| 12434312 | Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1 |
MAAVLESLLREEVSVAAVVRWIARSTQGSEDNAGEAAALSSLRALRKEFVPFLLNFLREQSSRVLPQGPP 1 - 70 TPAKTPGASAALPGRPGGPPRGSRGARSQLFPPTEAQSTAAEAPLARRGGRRRGPGPARERGGRGLEEGV 71 - 140 SGESLPGAGGRRLRGSGSPSRPSLTLSDPPNLSNLEEFPPVGSVPPGPTGTKPSRRINPTPVSEERSLSK 141 - 210 PKTCFTSPPISCVPSSQPSALDTSPWGLGLPPGCRSLQEEREMLRKERSKQLQQSPTPTCPTPELGSPLP 211 - 280 SRTGSLTDEPADPARVSSRQRLELVALVYSSCIAENLVPNLFLELFFVFQLLTARRMVTAKDSDPELSPA 281 - 350 VLDSLESPLFQSIHDCVFFAVQVLECHFQVLSNLDKGTLKLLAENERLLCFSPALQGRLRAAYEGSVAKV 351 - 420 SLVMPPSTQAVSFQPETDNRANFSSDRAFHTFKKQRDVFYEVLREWEDHHEEPGWDFEKGLGSRIRAMMG 421 - 490 QLSAACSHSHFVRLFQKQLLQMCQSPGGAGGTVLGEAPDVLSMLGADKLGRLWRLQERLMAPQSSGGPCP 491 - 560 PPTFPGCQGFFRDFILSASSFQFNQHLMDSLSLKIQELNGLALPQHEPNDEDGESDVDWQGERKQFAVVL 561 - 630 LSLRLLAKFLGFVAFLPYRGPEPPPTGELQDSILALRSQVPPVLDVRTLLQRGLQARRAVLTVPWLVEFL 631 - 700 SFADHVVPLLEYYRDIFTLLLRLHRSLVLSQESEGKMCFLNKLLLLAVLGWLFQIPTVPEDLFFLEEGPS 701 - 770 YAFEVDTVAPEHGLDNAPVVDQQLLYTCCPYIGELRKLLASWVSGSSGRSGGFMRKITPTTTTSLGAQPS 771 - 840 QTSQGLQAQLAQAFFHNQPPSLRRTVEFVAERIGSNCVKHIKATLVADLVRQAESLLQEQLVTQGEEGGD 841 - 910 PAQLLEILCSQLCPHGAQALALGREFCQRKSPGAVRALLPEETPAAVLSSAENIAVGLATEKACAWLSAN 911 - 980 ITALIRREVKAAVSRTLRAQGPEPAARGERRGCSRACEHHAPLPSHLISEIKDVLSLAVGPRDPDEGVSP 981 - 1050 EHLEQLLGQLGQTLRCRQFLCPPAEQHLAKCSVELASLLVADQIPILGPPAQYRLERGQARRLLHMLLSL 1051 - 1120 WKEDFQGPVPLQLLLSPRNVGLLADTRPREWDLLLFLLRELVEKGLMGRMEIEACLGSLHQAQWPGDFAE 1121 - 1190 ELATLSNLFLAEPHLPEPQLRACELVQPNRGTVLAQS 1191 - 1227 //
| PMID | Year | Title | |
|---|---|---|---|
| 24196372 | 2014 | Congenital dyserythropoietic anemia in China: a case report from two families and a review. | |
| 23716552 | 2013 | Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 22407294 | 2012 | Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply. | |
| 22223895 | 2012 | Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features. | |
| 21364188 | 2011 | Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts. | |
| 19336738 | 2009 | Codanin-1, the protein encoded by the gene mutated in congenital dyserythropoietic anemia type I (CDAN1), is cell cycle-regulated. | |
| 18575862 | 2008 | Congenital dyserythropoietic anemia in a Chinese family with a mutation of the CDAN1-gene. | |
| 18464913 | 2008 | A genome-wide association study identifies protein quantitative trait loci (pQTLs). | |
| 18081704 | 2008 | Congenital dyserythropoietic anaemia, type I, in a Caucasian patient with retinal angioid streaks (homozygous Arg1042Trp mutation in codanin-1). | |
| 17353931 | 2007 | Large-scale mapping of human protein-protein interactions by mass spectrometry. | |
| 16767397 | 2006 | Congenital dyserythropoietic anemia type I with bone abnormalities, mutations of the CDAN I gene, and significant responsiveness to alpha-interferon therapy. | |
| 16572171 | 2006 | Analysis of the DNA sequence and duplication history of human chromosome 15. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 12975309 | 2003 | The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12434312 | 2002 | Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. | |
| 8634422 | 1996 | Clinical features and studies of erythropoiesis in Israeli Bedouins with congenital dyserythropoietic anemia type I. |
