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Tchem HLA class II histocompatibility antigen gamma chain

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

 Comments

Property Summary

Ligand Count 7
NCBI Gene PubMed Count 126
PubMed Score 286.25
PubTator Score 193.65

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Cancer 2499 4.256 2.1

Expression

  Differential Expression (29)

Disease log2 FC p
active Crohn's disease 2.467 3.3e-03
active ulcerative colitis 2.570 4.6e-03
acute myeloid leukemia 1.200 4.1e-02
adrenocortical carcinoma -1.642 2.2e-02
adult high grade glioma 2.100 1.5e-02
astrocytic glioma 1.900 1.1e-02
Astrocytoma, Pilocytic 2.600 6.0e-05
atypical teratoid / rhabdoid tumor 1.500 2.1e-03
Becker muscular dystrophy 1.160 1.2e-03
Breast cancer 1.300 3.3e-02
Down syndrome 1.800 9.2e-04
Duchenne muscular dystrophy 1.553 2.3e-09
ependymoma 1.700 4.3e-02
esophageal adenocarcinoma 1.400 1.9e-02
glioblastoma 1.100 2.3e-02
interstitial cystitis 1.500 1.7e-02
invasive ductal carcinoma 1.479 2.5e-03
juvenile dermatomyositis 1.453 5.5e-08
limb girdle muscular dystrophy 2A 1.029 8.6e-05
lung cancer -2.100 1.3e-05
lung carcinoma -2.700 4.7e-43
non-small cell lung cancer -1.217 4.0e-06
osteosarcoma -1.863 4.6e-02
ovarian cancer -1.200 1.7e-02
pancreatic ductal adenocarcinoma liver m... 2.313 2.4e-03
primary Sjogren syndrome 2.100 5.0e-02
psoriasis -1.600 3.8e-03
Rheumatoid arthritis -2.900 1.4e-03
subependymal giant cell astrocytoma 2.101 4.6e-03

Synonym

Accession P04233 A8K7R1 B4DNE8 D3DQG3 D3DQG4 Q14597 Q29832 Q5U0J8 Q8SNA0 Q8WLP6
Symbols II
DHLAG
HLADG
Ia-GAMMA

Gene

CD74

PANTHER Protein Class (2)

PDB

1A6A   5KSU   5KSV   3PDO   3PGC   3PGD   3QXA   3QXD   4AEN   4AH2   4X5W   1ICF   1IIE   1L3H   1MUJ  

  Ortholog (1)

Species Source Disease
Chimp OMA Inparanoid

 UniProt Keyword (21)

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 GO Function (11)

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 GO Component (21)

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 GO Process (43)

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 Compartment GO Term (74)

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 MGI Phenotype (6)

 GWAS Trait (1)

 HCA RNA Cell Line (52)

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 CSPA Cell Line (18)

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Pathway (10)

Protein-protein Interaction (2)

COPG1   COPG2  

Ligand (7)

Structure of CHEMBL377684

CHEMBL377684
pIC50 6.01

Structure of CHEMBL204525

CHEMBL204525
pIC50 6.02

Structure of CHEMBL207003

CHEMBL207003
pIC50 6.03

Structure of CHEMBL377511

CHEMBL377511
pIC50 6.05

Structure of CHEMBL206745

CHEMBL206745
pIC50 6.09

Structure of CHEMBL408418

CHEMBL408418
pIC50 6.13

Structure of CHEMBL201461

CHEMBL201461
pIC50 6.39

Gene RIF (110)

AA Sequence 

MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYF      1 - 70
LYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTED     71 - 140
HVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVL    141 - 210
TKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDP    211 - 280
SSGLGVTKQDLGPVPM                                                          281 - 296
//

Text Mined References (135)

PMID Year Title