Tchem | HLA class II histocompatibility antigen gamma chain |
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Comments
Property Summary
Ligand Count | 7 |
NCBI Gene PubMed Count | 126 |
PubMed Score | 286.25 |
PubTator Score | 193.65 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Breast Neoplasms | 445 | 0.0 | 0.0 |
Carcinoma, Non-Small-Cell Lung | 107 | 0.0 | 0.0 |
Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
Liver Failure, Acute | 29 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Mammary Neoplasms | 425 |
non-small cell lung carcinoma | 317 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA |
CHEMBL377684
pIC50 6.01
CHEMBL204525
pIC50 6.02
CHEMBL207003
pIC50 6.03
CHEMBL377511
pIC50 6.05
CHEMBL206745
pIC50 6.09
CHEMBL408418
pIC50 6.13
CHEMBL201461
pIC50 6.39
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYF 1 - 70 LYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTED 71 - 140 HVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVL 141 - 210 TKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDP 211 - 280 SSGLGVTKQDLGPVPM 281 - 296 //