| Tbio | Hematopoietic progenitor cell antigen CD34 |
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cell Transformation, Neoplastic | 97 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 6.1e-17 |
| lung adenocarcinoma | 2716 | 5.3e-08 |
| psoriasis | 6694 | 5.6e-07 |
| glioblastoma | 5792 | 2.9e-05 |
| lung cancer | 4740 | 5.4e-04 |
| ductal carcinoma in situ | 1745 | 1.1e-03 |
| invasive ductal carcinoma | 2951 | 1.8e-03 |
| Atopic dermatitis | 952 | 4.4e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Heart disease | 306 | 3.514 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| Atopic dermatitis | -1.100 | 4.4e-03 |
| ductal carcinoma in situ | -1.500 | 1.1e-03 |
| glioblastoma | 1.100 | 2.9e-05 |
| invasive ductal carcinoma | -1.401 | 1.8e-03 |
| lung adenocarcinoma | -1.200 | 5.3e-08 |
| lung cancer | -1.300 | 5.4e-04 |
| non-small cell lung cancer | -1.314 | 6.1e-17 |
| psoriasis | -1.400 | 5.6e-07 |
MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGST 1 - 70 SLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSP 71 - 140 GNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGL 141 - 210 ARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDV 211 - 280 ASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQ 281 - 350 GKASVNRGAQENGTGQATSRNGHSARQHVVADTEL 351 - 385 //
