Tbio CD244 Natural killer cell receptor 2B4

Protein Summary

Description

Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8(+) T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity). This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9BZW8
• Q5VYI2
• Q5VYI6
• Q5VYI7
• Q96T47
• Q9NQD2
• Q9NQD3
• Q9Y288

Gene Name

• CD244

Ensembl ID

• ENST00000322302
• ENSP00000313619
• ENSG00000122223
• ENST00000368033
• ENSP00000357012
• ENST00000368034
• ENSP00000357013
• ENST00000492063
• ENSP00000432636

Symbol

• 2B4
• 2B4
• NAIL
• Nmrk
• NKR2B4
• SLAMF4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
biological term	0.68
gene perturbation	0.6
kinase perturbation	0.54
transcription factor	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Natural Killer Cell Receptor 2b4

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Natural Killer Cell Receptor 2b4

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Natural Killer Cell Receptor 2b4

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Natural Killer Cell Receptor 2b4

Protein / Cell Adhesion Molecule / Natural Killer Cell Receptor 2b4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.93   (req: < 5)

Gene RIFs: 79   (req: <= 3)

Antibodies: 667   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.93   (req: >= 5)

Gene RIFs: 79   (req: > 3)

Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0