Property Summary

NCBI Gene PubMed Count 17
PubMed Score 32.25
PubTator Score 28.19

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Expression

  Differential Expression (7)

Disease log2 FC p
Rheumatoid Arthritis -1.800 4.0e-02
psoriasis -1.200 4.4e-04
osteosarcoma -2.118 4.1e-06
lung adenocarcinoma -1.100 6.9e-16
adult high grade glioma 1.100 8.4e-05
lung carcinoma -1.700 9.8e-15
mucosa-associated lymphoid tissue lympho... 1.151 2.2e-02

Gene RIF (5)

PMID Text
25421756 Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.
23383108 A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of CD101 (IGSF2) in peptide-treated PBMCs
21467233 Single Nucleotide Polymorphism in CD101 gene may be associated with pancreatic cancer.
21159825 Results suggest a possible role for CD101 expression and function in the control of certain manifestations of rheumatoid arthritis pathology.
19898481 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSVYLPTNPTQEV      1 - 70
QIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYECHTPNTDEKYYGSYSAKTNL     71 - 140
IVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHLSVTWYLTQDGGGSQATEIISLSKDFILVPG    141 - 210
PLYTERFAASDVQLNKLGPTTFRLSIERLQSSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPA    211 - 280
VKDFQVNITADSLFAEGKPLELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGEL    281 - 350
QVSKLGPKAFSLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNK    351 - 420
QQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSYHGNTRLEKMD    421 - 490
WATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESSLQVSLMSRQPQVMLTNTFDL    491 - 560
SCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGTIEWGNFLSRFQKKTKVSQSLFRSQLLVHDA    561 - 630
TEEETGVYQCEVEVYDRNSLYNNRPPRASAISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSIL    631 - 700
SRSNGNLQLAIIWYFSPVSTNASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVED    701 - 770
SDRGKYHCAVEEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVG    771 - 840
SSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVEMEDAGMYWCR    841 - 910
VAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLFICPFVLLLLLLISLLCLYWK    911 - 980
ARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEGN                                 981 - 1021
//

Text Mined References (18)

PMID Year Title
25421756 2015 Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.
21467233 2011 Inflammation-related gene variants as risk factors for pancreatic cancer.
21159825 2011 CD101 expression and function in normal and rheumatoid arthritis-affected human T cells and monocytes/macrophages.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
19898481 2009 Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15737213 2005 CD4+ CD56+ blastic tumor cells express CD101 molecules.
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11504738 2001 EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.
11093127 2000 Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL-10 production.
10692025 2000 CD101 expression by Langerhans cell histiocytosis cells.
9647226 1998 V7 (CD101) ligation inhibits TCR/CD3-induced IL-2 production by blocking Ca2+ flux and nuclear factor of activated T cell nuclear translocation.
9389317 1997 CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation.
9233604 1997 Ligation of the V7 molecule on T cells blocks anergy induction through a CD28-independent mechanism.
7722300 1995 V7, a novel leukocyte surface protein that participates in T cell activation. II. Molecular cloning and characterization of the V7 gene.
7722299 1995 V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies.