| Tchem | C-C chemokine receptor type 9 |
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Comments
Property Summary
| Ligand Count | 86 |
| NCBI Gene PubMed Count | 59 |
| PubMed Score | 109.89 |
| PubTator Score | 105.71 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Inflammatory bowel disease | 151 | 4.833 | 2.4 |
| Primary sclerosing cholangitis | 14 | 3.323 | 1.7 |
CHEMBL3800351
pKi 7.00
CHEMBL3604477
pIC50 7.02
CHEMBL3815007
pIC50 7.03
CHEMBL3799853
pKi 7.04
CHEMBL3604478
pIC50 7.05
CHEMBL3799395
pKi 7.07
CHEMBL3814176
pIC50 7.07
CHEMBL3797948
pKi 7.11
CHEMBL3798577
pKi 7.11
CHEMBL3799220
pKi 7.13
CHEMBL3815051
pIC50 7.13
CHEMBL3800355
pKi 7.14
CHEMBL3814683
pIC50 7.16
CHEMBL3604496
pIC50 7.22
CHEMBL3799328
pKi 7.23
CHEMBL3798104
pKi 7.24
CHEMBL3798670
pKi 7.27
CHEMBL3604482
pIC50 7.28
CHEMBL3798206
pKi 7.29
CHEMBL3798681
pKi 7.35
MTPTDFTSPIPNMADDYGSESTSSMEDYVNFNFTDFYCEKNNVRQFASHFLPPLYWLVFIVGALGNSLVI 1 - 70 LVYWYCTRVKTMTDMFLLNLAIADLLFLVTLPFWAIAAADQWKFQTFMCKVVNSMYKMNFYSCVLLIMCI 71 - 140 SVDRYIAIAQAMRAHTWREKRLLYSKMVCFTIWVLAAALCIPEILYSQIKEESGIAICTMVYPSDESTKL 141 - 210 KSAVLTLKVILGFFLPFVVMACCYTIIIHTLIQAKKSSKHKALKVTITVLTVFVLSQFPYNCILLVQTID 211 - 280 AYAMFISNCAVSTNIDICFQVTQTIAFFHSCLNPVLYVFVGERFRRDLVKTLKNLGCISQAQWVSFTRRE 281 - 350 GSLKLSSMLLETTSGALSL 351 - 369 //
