Property Summary

NCBI Gene PubMed Count 1,189
PubMed Score 5447.09
PubTator Score 4570.69

Knowledge Summary


No data available


  Disease Sources (7)

Disease Target Count P-value
pilocytic astrocytoma 3086 7.5973852784504E-13
ependymoma 2514 9.56362143526484E-10
astrocytoma 1493 1.79542863880448E-9
ovarian cancer 8492 2.21973260275364E-7
psoriasis 6685 3.02181416955686E-7
colon cancer 1475 3.51756036644536E-6
oligodendroglioma 2849 3.53013630339807E-6
pediatric high grade glioma 2712 1.22353327086933E-5
atypical teratoid/rhabdoid tumor 1095 1.29605748117125E-5
malignant mesothelioma 3163 1.95242579844717E-5
pituitary cancer 1972 2.33144865706802E-4
cystic fibrosis 1670 2.45334592422748E-4
group 4 medulloblastoma 1875 2.65327916523193E-4
lung cancer 4473 5.05756956929304E-4
glioblastoma 5572 0.00104178371953731
medulloblastoma, large-cell 6234 0.00197204577548959
osteosarcoma 7933 0.00390794037521922
subependymal giant cell astrocytoma 2287 0.0149166547315744
primitive neuroectodermal tumor 3031 0.0197348265294934
Hydrolethalus syndrome 128 0.0365796685034155
Disease Target Count Z-score Confidence
Breast cancer 3099 0.0 2.0
Kidney cancer 121 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 7.551 3.8


  Differential Expression (21)

Disease log2 FC p
malignant mesothelioma -1.600 0.000
psoriasis -1.500 0.000
astrocytoma 1.200 0.000
oligodendroglioma 1.300 0.000
osteosarcoma 2.559 0.004
ependymoma 2.500 0.000
glioblastoma 2.300 0.001
cystic fibrosis 1.148 0.000
atypical teratoid/rhabdoid tumor 2.400 0.000
medulloblastoma, large-cell -1.100 0.002
primitive neuroectodermal tumor 2.000 0.020
Hydrolethalus syndrome 1.674 0.037
lung cancer 1.300 0.001
colon cancer 1.700 0.000
pediatric high grade glioma 2.300 0.000
group 4 medulloblastoma -1.700 0.000
pilocytic astrocytoma 2.700 0.000
subependymal giant cell astrocytoma 1.432 0.015
Breast cancer 1.100 0.004
ovarian cancer 3.300 0.000
pituitary cancer 1.100 0.000


Accession P24385 Q6LEF0
Symbols BCL1



2W96   2W99   2W9F   2W9Z  

  Ortholog (9)

Gene RIF (1164)

27025456 Data show that the fusion gene cyclin D1/myotonic dystrophy kinase-related CDC42-binding protein kinase alpha (CCND1/MRCK) mRNA is resistant to CCND1-targeted miRNA regulation.
26997441 BRAF inhibitor therapy-associated melanocytic lesions lack the BRAF V600E mutation and show increased levels of cyclin D1 expression.
26884359 Analysis of ctal carcinoma in situ (DCIS) by grade suggested that two independent SNPs near CCND1 were specific to low/intermediate grade DCIS . These associations with grade remained after adjusting for ER status and were also found in IDC
26834014 Together, these results demonstrate that PGC-1alpha regulates cell cycle progression through modulation of CyclinD1 and CyclinB1 by ATP and ROS.
26815661 The expressions of survivin and cycline D1 are positively correlated with the malignant potential of mucinous ovarian neoplasms.
26791264 Data indicated that HOXA1 and CCND1 mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC.
26728382 Data show that Cyclin D1 has a higher expression in breast cancer, positively correlated with estrogen receptors (ER) and better prognosis.
26708419 This inhibition was accompanied by a strong decrease in G1 cyclins (particularly in cyclin D1) and retinoblastoma protein (Rb) phosphorylation
26708311 All of the results confirmed that CD73 promotes the growth of human colorectal cancer cells through EGFR and the b-catenin/cyclin D1 signaling pathway. CD73 may be used as a valuable biomarker of colorectal cancer.
26707131 The potent antitumor activity of RHL may be mediated through downregulation of Bcl-2 and cyclin D expression and upregulation of BAX and Bim expression.

AA Sequence

VDLACTPTDVRDVDI                                                           281 - 295

Text Mined References (1193)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
27025456 2016 Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma.
26997441 2016 BRAF inhibitor therapy-associated melanocytic lesions lack the BRAF V600E mutation and show increased levels of cyclin D1 expression.
26884359 2016 Genetic predisposition to ductal carcinoma in situ of the breast.
26834014 2016 PGC-1? regulates the cell cycle through ATP and ROS in CH1 cells.
26815661 2016 Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms.
26791264 2016 Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1.
26728382 2016 [High expression of cyclin D1 is correlated with the expression of estrogen receptor and good prognosis in breast cancer].
26708419 2016 The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin.
26708311 2016 Effects of CD73 on human colorectal cancer cell growth in vivo and in vitro.