| Tbio | C-C motif chemokine 8 |
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Rheumatoid | 174 | 0.0 | 0.0 |
| Hypersensitivity | 63 | 0.0 | 0.0 |
| Influenza, Human | 51 | 0.0 | 0.0 |
| Nephrogenic Fibrosing Dermopathy | 3 | 0.0 | 0.0 |
| Pneumonia | 174 | 0.0 | 0.0 |
| Respiratory Hypersensitivity | 19 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Influenza | 142 |
| Rheumatoid arthritis | 1191 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 2.2e-37 |
| juvenile dermatomyositis | 1187 | 1.3e-09 |
| Astrocytoma, Pilocytic | 3081 | 1.4e-05 |
| cutaneous lupus erythematosus | 1057 | 3.5e-05 |
| medulloblastoma, large-cell | 6241 | 2.3e-04 |
| nasopharyngeal carcinoma | 1058 | 1.3e-03 |
| ependymoma | 4679 | 1.4e-03 |
| glioblastoma | 5792 | 1.5e-03 |
| ovarian cancer | 8520 | 1.8e-03 |
| adrenocortical carcinoma | 1428 | 3.2e-03 |
| interstitial cystitis | 2312 | 3.4e-03 |
| adult high grade glioma | 3801 | 3.5e-03 |
| lung cancer | 4740 | 5.0e-03 |
| head and neck cancer and chronic obstructive pulmonary disease | 239 | 5.8e-03 |
| tuberculosis | 2010 | 7.0e-03 |
| Breast cancer | 3578 | 9.2e-03 |
| aldosterone-producing adenoma | 665 | 1.1e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.4e-02 |
| adrenocortical adenoma | 131 | 2.2e-02 |
| COPD | 118 | 2.4e-02 |
| colon cancer | 1478 | 2.6e-02 |
| invasive ductal carcinoma | 2951 | 3.6e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.1e-02 |
| sarcoidosis | 370 | 4.2e-02 |
| ulcerative colitis | 1819 | 4.2e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical adenoma | -1.302 | 2.2e-02 |
| adrenocortical carcinoma | -1.651 | 3.2e-03 |
| adult high grade glioma | 1.700 | 3.5e-03 |
| aldosterone-producing adenoma | -1.311 | 1.1e-02 |
| Astrocytoma, Pilocytic | 1.300 | 1.4e-05 |
| atypical teratoid / rhabdoid tumor | 1.200 | 1.4e-02 |
| Breast cancer | 1.200 | 9.2e-03 |
| colon cancer | -1.700 | 2.6e-02 |
| COPD | 1.600 | 2.4e-02 |
| cutaneous lupus erythematosus | 4.400 | 3.5e-05 |
| ependymoma | 1.300 | 1.4e-03 |
| glioblastoma | 1.300 | 1.5e-03 |
| head and neck cancer and chronic obstruc... | 1.800 | 5.8e-03 |
| interstitial cystitis | 1.200 | 3.4e-03 |
| intraductal papillary-mucinous adenoma (... | -1.600 | 4.1e-02 |
| intraductal papillary-mucinous carcinoma... | -1.600 | 4.6e-02 |
| invasive ductal carcinoma | -1.253 | 3.6e-02 |
| juvenile dermatomyositis | 2.829 | 1.3e-09 |
| lung cancer | -1.200 | 5.0e-03 |
| medulloblastoma, large-cell | 1.100 | 2.3e-04 |
| nasopharyngeal carcinoma | 2.000 | 1.3e-03 |
| ovarian cancer | 2.000 | 1.8e-03 |
| psoriasis | 1.600 | 2.2e-37 |
| sarcoidosis | 2.300 | 4.2e-02 |
| tuberculosis | -1.700 | 7.0e-03 |
| ulcerative colitis | 1.300 | 4.2e-02 |
