| Tbio | C-C motif chemokine 16 |
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.2e-07 |
| osteosarcoma | 7950 | 1.8e-07 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Lisch epithelial corneal dystrophy | 4 | 5.835 | 2.9 |
| Subacute sclerosing panencephalitis | 11 | 4.572 | 2.3 |
| Measles | 22 | 3.256 | 1.6 |
| Breast cancer | 3578 | 3.169 | 1.6 |
| Eosinophilic pneumonia | 5 | 3.063 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -2.639 | 1.8e-07 |
| ovarian cancer | 1.100 | 1.2e-07 |
