Property Summary

NCBI Gene PubMed Count 169
PubMed Score 945.24
PubTator Score 204.73

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (8)

Disease log2 FC p
non diabetic and post-ischemic heart fai... -1.300 2.5e-03
medulloblastoma, large-cell 1.200 6.5e-04
colon cancer -1.500 2.4e-02
lung cancer -2.000 1.5e-04
interstitial cystitis 3.500 1.3e-04
ulcerative colitis 1.900 1.7e-03
ovarian cancer 1.600 1.9e-02
psoriasis 2.000 1.0e-08

Gene RIF (144)

PMID Text
26907493 ANDV caused long-term elevated levels of eotaxin-1, IL-6, IL-8, IP-10, and VEGF-A that peaked 20-25 days after infection
26699196 co-cultures of KYSE-410 cells and cancer-associated fibroblasts (CAF) were investigated. Similar to SF, Has2 and Ccl5 were up-regulated and Ccl11 was down-regulated in CAF in co-culture.
26491210 The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.
26359802 Findings demonstrate a link between CCL11 and primary Sjogren's syndrome disease activity and lymphoma.
26341115 increased amounts released by neutrophils from fibromyalgia patients
26324103 The results of this study suggested that eotaxin-1 as a novel modifier of Alzheimer's disease age at onset and open potential avenues for therapy.
26306920 Serum and urinary CCL11 were decreased in patients with prostate cancer compared with controls.
26270578 Eotaxin measured on the day of birth is useful for identifying extremely low birth weight infants at risk of bronchopulmonary dysplasia/death.
26241961 we identify higher levels of CRP, eotaxin and MCP-1 in serum of periodontitis patients
25645983 IL-1b can substantially stimulate the secretion of eotaxin and RANTES in nasal polyp-derived fibroblasts.
25620704 The gene expression of eotaxin increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates eotaxin protein expression
25450766 Results show the structure of CCL11 bound to the sulfated N-terminal region of its receptor CCR3 and show that intact CCR3 is sulfated and sulfation enhances receptor activity.
25393692 SF of BC OA displayed significantly higher concentrations for a number of proinflammatory cytokines [CXCL1, eotaxin, interferon (IFN)-gamma, interleukin (IL)-7, IL-8, IL-9, IL-12].
25237944 the CCL11 GG genotype is a significant risk factor for ischemic as well as hemorrhagic stroke. Further, the frequency of the GG genotype was observed to be higher in hemorrhagic stroke patients in comparison with ischemic stroke.
25111027 Taken together, these findings indicate that inhibiting IL-4-induced eotaxin-1 expression by synephrine occurs primarily through the suppression of eosinophil recruitment, which is mediated by inhibiting STAT6 phosphorylation.
25080789 The detection of basal level of IgM rheumatoid factor, IgM and also certain cytokines can be useful in prognosis of effectiveness of rituximab therapy under rheumatoid arthritis.
24647150 High eotaxin and MCP-1 at follow-up was predicted by early disease parameters, and MCP-1 was associated with organ damage at follow-up, highlighting a role of these chemokines in juvenile dermatomyositis.
24604010 eotaxin-1 increases MMP-3 expression via the CCR3-ERK pathway, thereby promoting prostate cancer cell invasion and migration.
24600981 CCL11, CCL24, and CCL26 are increased in TB patients; hence, it seems that TB suppresses Th1 and the classic function of macrophages subsequently by inducing the chemokines' expression
24482230 thi is a study of the interaction between vCCI and eotaxin-1 (CCL11), a CC chemokine that is an important factor in the asthma response.
24273921 elevated levels of CCL5 and CCL11 are in parallel with decreased level of CCL2 and are useful tools in the differential diagnosis of T1D from other types of metabolic disorders
23904440 CCL11 contributes to eosinophil recruitment in UC and that intestinal myeloid cells are a source of CCL11.
23820464 Cannabis use was found to increase CCL11 plasma levels and the effects were reversed when cannabis use ceases.
23477905 CCL11, CCL24, and CCL26 has a role in the recruitment of extravillous trophoblast into decidual tissue and vessels.
23180368 serum levels of CCL2 and CCL11 were significantly enhanced in food allergic patients compared to control but CCL5 was not detectable
23114905 the eotaxin/CCL11-CCR3 axis is active in idiopathic retroperitoneal fibrosis (IRF) and may contribute to its pathogenesis; the TTCCAT haplotype within the CCL11 gene is significantly associated with IRF
23061798 These data uncover a previously unknown role for NRF2 in regulating Eotaxin-1 expression and further the mechanistic understanding of this pathway in modulating inflammatory lung disease.
23059958 Serum levels for CCL1 (I-309) were significantly elevated among all men with enlarged prostates (P < 0.04). Serum levels for CCL11 (Eotaxin-1) were significantly elevated among men with prostate cancer regardless of prostate size (P < 0.01).
23049769 The Marfan syndrome patients with lowest mental quality of life and vitality scores had high levels of CCL11 cytokine.
22846146 The level of eotaxin expression and inflammatory cell count were measured in the material from nasal brushing in healthy controls and in patients with allergic rhinitis, asthma, and chronic obstructive pulmonary disease.
22775568 Serum CCL17, IL-8, and eotaxin levels were significantly increased in eosinophilic subjects as compared to normal controls, but were similar between Churg-syndrome and hypereosinophilic syndrome.
22773402 The impact of three single-nucleotide polymorphisms in eotaxin (SCYA11) gene promoter (-426C>T and -384A>G) and first exon (67G>A) and recently described hexanucleotide (GAAGGA)(n) 10.9 kb upstream on coronary atherosclerosis was investigated.
22271279 Study found that the plasma concentration of eotaxin was associated with the clinical severity of chronic rhinosinusitis in Taiwanese patients.
22114952 Eotaxin-1 not only induces MMP-3 gene expression but also promotes MMP-3 protein secretion through G protein-coupled eotaxin-1 receptor activities.
21825098 In this study, eotaxin-1 -384 A>G or 67 G>A genotypes were not associated with susceptibility to Nasal Polyposis.
21601544 Pretreated CCD-11Lu cells with noncytotoxic doses (0.1-10 muM) of CAPE inhibited the production of eotaxin under stimulation of IL-4 and tnf-alpha.CAPE pretreatment decreased the amount of pSTAT6 and STAT6 DNA binding complexes in nuclear extracts.
21406396 Data show that expression levels of CCL11 and CCR3 mRNA in the lesional skin of ALCL were significantly higher than those in normal skin.
21368236 Eotaxin induces proliferation of nonasthmatic airway smooth muscle cells and decreases their rate of apoptosis.
21077277 Serum CCL11 was increased in ulcerative colitis (UC) and less in Crohn's disease (CD), whereas CCL24 and CCL26 were increased only in UC. Colon expression of the CCL's was higher in UC vs. CD, and was induced by Th2 cytokines in colon epithelial cells.
21052690 Observational study of gene-disease association. (HuGE Navigator)
20934424 SOCS1 and 3 may control chemotaxis and adhesion
20704746 Measurements of eotaxin-1 in exhaled breath condensate of asthma patients may provide a useful diagnostic tool for detecting and monitoring airway inflammation and disease severity.
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20603037 Observational study of gene-disease association. (HuGE Navigator)
20536507 genetic variants, including Ala/Ala of SCYA11 (eotaxin) Ala23Thr, Cys/Cys or Cys/Ser of PON2 (paraoxonase 2) Ser311Cys and Arg/Arg of ADRB3 (beta3-adrenergic receptor) Trp64Arg, were independently associated with incident cardiac end-point.
20536507 Observational study of gene-disease association. (HuGE Navigator)
20505746 interaction of eotaxins and CCR3 regulates the Th2-dominant tumor environment, which is closely related to the development of cutaneous T-cell lymphoma
20503287 Observational study of gene-disease association. (HuGE Navigator)
20444156 elevated levels of eotaxin in children with stable asthma; correlation with eosinophilia
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20406964 Observational study of gene-disease association. (HuGE Navigator)
20306659 Data show that both plasma eotaxin level and expression of CCR3 on CD4+ T cells were higher in allergic patients than controls in different types of allergy.
20237496 Observational study of gene-disease association. (HuGE Navigator)
20236835 The mean gene expression level for CCL11, CCL24, CCL26 was higher in skin changes of atopic dermatitis patients than in uninvolved skin.
20227754 Circulating endothleial progenitor cells of asthmatic patients had higher levels of eotaxin-1 compared with those seen in control subjects.
20056178 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19948975 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
19937162 Serum CCL18 level was significantly decreased in epithelial ovarian cancer patients with early stages compared to those with late stages.
19925666 IL-2 and eotaxin-1 levels may be important markers of disease stability in chronic obstructive pulmonary disease.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19865101 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19729601 Observational study of gene-disease association. (HuGE Navigator)
19578796 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19559392 Observational study of gene-disease association. (HuGE Navigator)
19522186 After corticosteroid therapy, the expressions of Eotaxin and Eotaxin-2 in mucosal epithelia of nasal polyps were significantly decreased.
19479237 Observational study of gene-disease association. (HuGE Navigator)
19423540 Observational study of gene-disease association. (HuGE Navigator)
19351767 CCL11 signaling plays an important role in proliferation and invasion of ovarian carcinoma cells and CCL11 pathway could be targeted for therapy in ovarian cancer.
19338989 IL-4 induces eotaxin in ectopic endometrial stromal cells, which might promote angiogenesis and subsequent development of endometriosis.
19264973 Observational study of gene-disease association. (HuGE Navigator)
19263529 Observational study of gene-disease association. (HuGE Navigator)
19258923 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19247692 Observational study of gene-disease association. (HuGE Navigator)
19131662 Meta-analysis of gene-disease association. (HuGE Navigator)
19056482 Observational study of gene-disease association. (HuGE Navigator)
19028820 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18981162 intestinal macrophage and epithelial cell-derived eotaxin-1 plays a critical role in the regulation of eosinophil recruitment in colonic eosinophilic disease such as pediatric ulcerative colitis
18974840 Observational study of gene-disease association. (HuGE Navigator)
18971287 CCL11 induces SOCS1 and SOCS3 expression in murine macrophages, human monocytes, and dendritic cells and inhibits GM-CSF-mediated STAT5 activation and IL-4-induced STAT6 activation in a range of hematopoietic cells.
18950617 activation of prostanoid thromboxane A(2) receptors in a Th2-dominant microenvironment might exacerbate the eosinophilic inflammation of the airways by synthesis and release of CCL11 from bronchial smooth muscle cells
18844613 Gene expression of eotaxin-1/CCL11 showed relevant downregulation in four cases and a modest twofold decrease in three of the patients studied with EE treated with topical steroids.
18714023 protein kinase C betaII augments NF-kappaB-mediated TNF-alpha-induced transcription of the target gene CCL11, promoting p65 association with the CCL11 promoter, in human airway smooth muscle cells by phosphorylating p300/CBP-associated factor
18712274 Eotaxin-1, Eotaxin-2 and Eotaxin-3 gene polymorphisms and gene-gene interactions among them are associated with the development of asthma.
18712274 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18699931 CCL11 mediates airway smooth muscle migration
18523302 In a collagen matrix three-dimensional model, CCL11-induced eosinophil migration is fully dependent on both RhoA GTP-binding protein and Rho-associated protein kinase (ROCK).
18515987 There are elevated concentrations of the chemokines MDC, eotaxin, I-TAC, and MCP-1 in malignant pleural effusions.
18398743 except for IL-6 and eotaxin, CLL B-cells and their normal counterparts produce and secrete similar amounts of cytokines and cytokine receptors in vitro.
18380907 Gram-negative bacteria inhibited the release of eotaxin-1 from human airway smooth muscle cells.
18312691 This study raises the hypothesis that high serum levels of eotaxin predict less radiographic progression in early RA patients.
18312459 the eotaxin gene may play a crucial role in the development of extrinsic Atopic Dermatitis, probably with other genetic factors.
18312459 Observational study of gene-disease association. (HuGE Navigator)
18203973 Results suggest that dexamethasone, depending on the exposure duration, can either inhibit or enhance IL-4-induced expression and production of eotaxin in lung fibroblasts.
18055844 Developing lung expresses the eotaxins and functional CCR3 receptor.
17845580 This study finding provide a strong evidence that Eotaxin 1 Thr23Thr homozygote has a protective effect on asthma and significantly decreases plasma Eotaxin 1 concentrations in asthmatics in Taiwan.
17827376 There were significantly greater concentrations of the chemokines CCL3 and CCL11 in plasma of leprosy patients than in non-infected individuals
17703412 Observational study of gene-disease association. (HuGE Navigator)
17672898 Eotaxin-1 protein levels in colorectal tumours were significantly (P < 0.0001) higher than in normal tissue
17620002 A significant correlation exists between bronchoalveolar lavage concentration of CCL11 and eosinophils in veterans with sulfur mustard gas-induced pulmonary fibrosis.
17541284 The Th2 cytokine IL-4 preferentially stimulated eotaxin expression. IL-4 activated the eotaxin promoter and STAT6 binding to it.
17438850 Corticosteroid treatment of nasal polyps reduced expression of CCL11.
17438849 The expression of Eotaxin-1 and -2 in nasal polyposis and polyps was dramatically higher than in controls.
17220216 A highly significant association of the newly studied (GAAGGA)(n) hexanucleotide repeat with asthma (p = 3x10(-6)), log(10)TsIgE (p = 0.006) and eotaxin levels (p = 0.004) was observed.
17016617 Observational study of gene-disease association. (HuGE Navigator)
16879311 serum expression of eotaxin & IL-5 were significantly increased in patients with strongyloidiasis compared with controls; this rise suggests that selective mediators of the eosinophil can have a role in immunity against S. stercoralis in human infection
16874958 Eotaxin may up-regulate the expression of VCAM-1 in vessel endothelium and promote adhesion and migration of eosinophils, as a result, to lead to the recurrence of nasal polyps.
16872505 Observational study of gene-disease association. (HuGE Navigator)
16864713 Observational study of gene-disease association. (HuGE Navigator)
16517749 mast cell beta-tryptase selectively cleaves asthmatic airway smooth muscle (ASM)-derived eotaxin and RANTES and abrogates their chemotactic activities, thus providing an explanation for the eosinophil paucity in asthmatic ASM bundles
16510147 Observational study of gene-disease association. (HuGE Navigator)
16510147 Eotaxin (CCL11) is a CC chemokine, whose systemic levels might be associated with coronary artery disease (CAD) and genetic variants predispose to the myocardial infarction (MI).
16461130 Observational study of gene-disease association. (HuGE Navigator)
16461130 Single nucleotide polymorphisms at the CCL11 locus is an important determinant of serum total IgE levels among patients with asthma.
16391516 Observational study of gene-disease association. (HuGE Navigator)
16184405 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
16029496 Cigarette smoke may directly cause the release of IL-8 from HASMC, an effect enhanced by TNF-alpha which is overexpressed in COPD
15661912 Observational study of gene-disease association. (HuGE Navigator)
15537425 However, In the presence of TNF-alpha, melatonin promoted RANTES melatonin, respectively) expression in a dose dependent manner in A549 cells).
15389872 Results show that human chondrocytes express eotaxin-1, that its expression is induced by treatment with interleukin-1beta and TNF-alpha, and suggest that it plays an important role in cartilage degradation in osteoarthritis.
15223611 Asthmatics who were vaccinated with a single dose of influenza subunit vaccine showed elevated eotaxin seum levesls.
15207712 Observational study of gene-disease association. (HuGE Navigator)
15207712 Our results suggest that the polymorphisms of the eotaxin gene family are associated with the susceptibility of asthma and Eotaxin-3 might play the critical role for the recruitment of eosinophils and the maintenance of IgE levels.
15186951 Observational study of gene-disease association. (HuGE Navigator)
14733956 the two N-terminal motifs of eotaxin must cooperate with other regions to successfully bind and activate CCR3
14725564 High local levels of eotaxin as present in the blister fluid correspond to the high state of activation of the infiltrated eosinophils in tissue eosinophilia in pemphigoid gestationis
14571188 Observational study of gene-disease association. (HuGE Navigator)
12949249 CCL11 is an antimicrobial protein with bacteriocidal activity against E. coli and S. aureus.
12916705 Production of Eotaxin by eosinophils already within nasal polyps is likely an important mecahanism by which even more eosinophils may be recruited into the polyp tissue.
12915771 IL-5 and eotaxin are associated with acute exacerbation of asthma.
12884299 eosinophil responses mediated by chemokines acting at CCR3 may be regulated by two distinct mechanisms: the antagonistic effects of CXCR3 ligands and the sequestration of CCL11 by CXCR3-expressing cells
12393570 results suggest that expression of chemokine receptor 3(CCR3) and its ligand eotaxin/CCL11 plays a role in the recruitment and retention of CD30(+) malignant T cells to the skin
12392390 Infiltrating eosinophils that express eotaxin and the changes of blood eotaxin levels during steroid therapy suggest that eotaxin may be associated with idiopathic eosinohilic esophagitis
12370400 Eotaxin-1 protein and mRNA are synergistically up-regulated in airway fibroblasts from asthmatic and normal subjects by TGF-beta 1 and IL-13 in combination.
12234713 Observational study of gene-disease association. (HuGE Navigator)
12193745 Intradermal injection of CCL11 induces recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions in atopic and nonatopic volunteers.
12192108 Pretreatment or co-treatment with each of the eotaxins augmented PMAtate-induced superoxide generation, concentration-dependent degranulation of eosinophil peroxidase, & potentiation of A23187-induced degranulation.
12082592 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
12065904 Histamine and serotonin stimulate eotaxin and augment the expression of eotaxin mRNA production by a human lung fibroblast cell line.
11991282 bronchial expression increased in exacerbated chronic bronchitis
11966763 Expression of eotaxin parallels eosinophil accumulation in the vesiculobullous stage of incontinentia pigmenti
11884459 Eotaxin/CCL11 may down-regulate production of the neutrophil chemoattractant IL-8/CXCL8 by vascular endothelial cells in vivo, acting as a negative regulator of neutrophil recruitment.
11742272 Observational study of gene-disease association. (HuGE Navigator)
8674119 The gene expression of eotaxin increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates eotaxin protein expression

AA Sequence

MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAK      1 - 70
DICADPKKKWVQDSMKYLDQKSPTPKP                                                71 - 97
//

Text Mined References (169)

PMID Year Title
26907493 2016 Andes Hantavirus-Infection of a 3D Human Lung Tissue Model Reveals a Late Peak in Progeny Virus Production Followed by Increased Levels of Proinflammatory Cytokines and VEGF-A.
26699196 2016 Esophageal Squamous Cell Carcinoma Cells Modulate Chemokine Expression and Hyaluronan Synthesis in Fibroblasts.
26491210 2015 The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease.
26359802 2015 CXCL13 and CCL11 Serum Levels and Lymphoma and Disease Activity in Primary Sjögren's Syndrome.
26341115 2016 Altered release of chemokines by phagocytes from fibromyalgia patients: a pilot study.
26324103 2015 Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease.
26306920 2015 Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence?
26270578 2015 Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death.
26241961 2015 Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines.
25645983 2015 Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps.
25450766 2014 Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1.
25393692 2015 Unicompartmental and bicompartmental knee osteoarthritis show different patterns of mononuclear cell infiltration and cytokine release in the affected joints.
25237944 Association of -1382A>G CCL11 gene variant with ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population.
25111027 2014 Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.
25080789 2014 [The immunologic predictors of effect of anti-B-cell therapy under rheumatoid arthritis].
24647150 2014 Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage.
24604010 2014 Eotaxin-1 promotes prostate cancer cell invasion via activation of the CCR3-ERK pathway and upregulation of MMP-3 expression.
24600981 2014 All eotaxins CCL11, CCL24 and CCL26 are increased but to various extents in pulmonary tuberculosis patients.
24482230 2014 Structural insights into the interaction between a potent anti-inflammatory protein, viral CC chemokine inhibitor (vCCI), and the human CC chemokine, Eotaxin-1.
24273921 2013 Expression of CC chemokines CCL2, CCL5, and CCL11 is associated with duration of disease and complications in type-1 diabetes: a study on Iranian diabetic patients.
23904440 2013 CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis.
23820464 2013 Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers.
23679817 2013 Inhibition by new glucocorticoid antedrugs [16?, 17?-d] isoxazoline and [16?, 17?-d]-3'-hydroxy-iminoformyl isoxazoline derivatives of chemotaxis and CCL26, CCL11, IL-8, and RANTES secretion.
23597562 2013 Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.
23532518 2013 CCL26/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11/eotaxin-1 and CCL24/eotaxin-2.
23496801 2013 Serum CCL11 (eotaxin-1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans.
23477905 2013 Control of extravillous trophoblast function by the eotaxins CCL11, CCL24 and CCL26.
23180368 2013 Serum levels of the CC chemokines CCL2, CCL5, and CCL11 in food allergic children with different clinical manifestations.
23149666 2013 The C-C motif chemokine ligands CCL5, CCL11, and CCL24 induce the migration of circulating fibrocytes from patients with severe asthma.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
23114905 2012 Eotaxin/CCL11 in idiopathic retroperitoneal fibrosis.
23061798 2012 Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene.
23059958 2013 CCL11 (eotaxin-1): a new diagnostic serum marker for prostate cancer.
23049769 2012 Mental quality of life is related to a cytokine genetic pathway.
22846146 2012 Expression of eotaxins in the material from nasal brushing in asthma, allergic rhinitis and COPD patients.
22775568 2012 Serum biomarkers are similar in Churg-Strauss syndrome and hypereosinophilic syndrome.
22773402 2012 Association between three single nucleotide polymorphisms in eotaxin (CCL 11) gene, hexanucleotide repetition upstream, severity and course of coronary atherosclerosis.
22412388 2012 A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
22271279 2012 Plasma RANTES and eotaxin levels are correlated with the severity of chronic rhinosinusitis.
22114952 2011 Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes.
21825098 2011 Lack of association between eotaxin-1 gene polymorphisms and nasal polyposis.
21601544 2011 Caffeic acid phenethyl ester suppresses eotaxin secretion and nuclear p-STAT6 in human lung fibroblast cells.
21406396 2011 CCL11-CCR3 interactions promote survival of anaplastic large cell lymphoma cells via ERK1/2 activation.
21368236 2011 CC and CXC chemokines induce airway smooth muscle proliferation and survival.
21314817 2011 Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-?.
21077277 2010 Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies.
21052690 2011 The 5352 A allele of the pro-inflammatory caspase-1 gene predicts late-acquired stent malapposition in STEMI patients treated with sirolimus stents.
20934424 2010 Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.
20704746 2010 Eotaxin-1 in exhaled breath condensate of stable and unstable asthma patients.
20628624 2010 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20603037 2010 Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.
20536507 2010 Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients.
20505746 2010 Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma.
20503287 2010 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
20444156 2010 The roles of a Th2 cytokine and CC chemokine in children with stable asthma: potential implication in eosinophil degranulation.
20438785 2010 Polymorphisms in innate immunity genes and risk of childhood leukemia.
20406964 2010 Risk of meningioma and common variation in genes related to innate immunity.
20306659 2007 Circulating chemokine eotaxin and chemokine receptor CCR3 in allergic patients.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20236835 2010 Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eotaxin 3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis.
20227754 2010 Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia.
20056178 2010 Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
20041150 2009 Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels.
19948975 2009 Integrative predictive model of coronary artery calcification in atherosclerosis.
19937162 2010 Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer.
19925666 2009 Eosinophil and T cell markers predict functional decline in COPD patients.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19865101 2010 Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.
19729601 2009 Candidate gene polymorphisms for ischemic stroke.
19578796 2009 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
19559392 2009 A candidate gene association study of 77 polymorphisms in migraine.
19525930 2009 CCR3 is a target for age-related macular degeneration diagnosis and therapy.
19522186 2009 [Effects of corticosteroid on Eotaxin and Eotaxin-2 in nasal polyps].
19479237 2009 Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling.
19423540 2009 Common variation in genes related to innate immunity and risk of adult glioma.
19351767 2009 Role of eotaxin-1 signaling in ovarian cancer.
19338989 2010 Interleukin-4 induces expression of eotaxin in endometriotic stromal cells.
19264973 2009 Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
19263529 2009 Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
19258923 2009 Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
19247692 2009 Analyses of associations with asthma in four asthma population samples from Canada and Australia.
19131662 2009 A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
19056482 2009 Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome.
19028820 2009 Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.
18981162 2008 Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis.
18974840 2008 Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis.
18971287 2009 CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression.
18950617 2008 TP receptor-mediated release of eosinophil chemotactic activity from human bronchial smooth muscle cells.
18844613 2008 Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis.
18714023 2008 PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation.
18712274 2008 Genetic interactions model among Eotaxin gene polymorphisms in asthma.
18699931 2008 The airway smooth muscle CCR3/CCL11 axis is inhibited by mast cells.
18523302 2008 CCL11 and GM-CSF differentially use the Rho GTPase pathway to regulate motility of human eosinophils in a three-dimensional microenvironment.
18515987 2008 The local cytokine and chemokine milieu within malignant effusions.
18398743 2008 Protein expression profiling of cytokines and cytokine receptors on purified chronic lymphocytic leukemia cells from patients with favourable prognostic indicators.
18380907 2008 Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells.
18312691 2008 A high serum level of eotaxin (CCL 11) is associated with less radiographic progression in early rheumatoid arthritis patients.
18312459 2008 Investigation of the eotaxin gene -426C-->T, -384A-->G and 67G-->a single-nucleotide polymorphisms and atopic dermatitis in Italian children using family-based association methods.
18275857 2008 Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8.
18203973 2008 Differential regulation of eotaxin expression by dexamethasone in normal human lung fibroblasts.
18055844 2008 Ontogeny of the eotaxins in human lung.
17845580 2007 The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan.
17827376 2007 Differentiation of patients with leprosy from non-infected individuals by the chemokine eotaxin/CCL11.
17703412 2007 Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
17672898 2007 Analysis of single nucleotide polymorphism in the promoter and protein expression of the chemokine eotaxin-1 in colorectal cancer patients.
17620002 2007 Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis.
17541284 2007 Differential regulation of chemokine expression by Th1 and Th2 cytokines and mechanisms of eotaxin/CCL-11 expression in human airway smooth muscle cells.
17438850 2007 [Effects of systemic corticosteroids on expression of Eotaxin in nasal polyps].
17438849 2007 [Expression and significance of Eotaxin and Eotaxin-2 in nasal polyposis and nasal polyp tissue].
17220216 2007 A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels.
17016617 2006 Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis.
16879311 2006 Eosinophil-selective mediators in human strongyloidiasis.
16874958 2005 [Vascular cell adhesion molecule-1, eotaxin and vascular endothelial growth factor in nasal polyps after endoscopic surgery].
16872505 2006 An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians.
16864713 2006 A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease.
16517749 2006 Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.
16510147 2006 Influence of eotaxin 67G>A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls.
16461130 2006 Eotaxin polymorphisms and serum total IgE levels in children with asthma.
16391516 2005 The association of eotaxin-2 and eotaxin-3 gene polymorphisms in a Korean population with ulcerative colitis.
16184405 2005 Interaction between inflammation-related gene polymorphisms and cigarette smoking on the risk of myocardial infarction in the Physician's Health Study.
16029496 2005 Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle.
15661912 2005 A single nucleotide polymorphism on the promoter of eotaxin1 associates with its mRNA expression and asthma phenotypes.
15537425 2004 Melatonin promoted chemotaxins expression in lung epithelial cell stimulated with TNF-alpha.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15389872 2004 Production of the chemokine eotaxin-1 in osteoarthritis and its role in cartilage degradation.
15223611 2004 Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
15207712 2004 Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil.
15186951 2004 Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction.
15067078 2004 Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor.
14733956 2004 Eotaxin and monocyte chemotactic protein-3 use different modes of action.
14725564 2004 Tissue eosinophilia in pemphigoid gestationis: association with eotaxin and upregulated activation markers on transmigrated eosinophils.
14571188 2003 MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission.
12949249 2003 Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.
12916705 2003 Localization and quantitation of eotaxin mRNA in human nasal polyps.
12915771 2003 Association of interleukin-5 and eotaxin with acute exacerbation of asthma.
12884299 2003 CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12393570 2003 Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma.
12392390 2002 Infiltrating eosinophils and eotaxin: their association with idiopathic eosinophilic esophagitis.
12370400 2002 TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts.
12234713 2002 Eotaxin gene single nucleotide polymorphisms in the promoter and exon regions are not associated with susceptibility to atopic dermatitis, but two of them in the promoter region are associated with serum IgE levels in patients with atopic dermatitis.
12193745 2002 Eotaxin (CCL11) and eotaxin-2 (CCL24) induce recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions following cutaneous injection in human atopic and nonatopic volunteers.
12192108 2002 Regulatory effects of eotaxin, eotaxin-2, and eotaxin-3 on eosinophil degranulation and superoxide anion generation.
12082592 2002 Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease.
11991282 2002 Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis.
11966763 2002 Expression of eotaxin, an eosinophil-selective chemokine, parallels eosinophil accumulation in the vesiculobullous stage of incontinentia pigmenti.
11884459 2002 Eotaxin/CCL11 suppresses IL-8/CXCL8 secretion from human dermal microvascular endothelial cells.
11742272 2001 Variant eotaxin: its effects on the asthma phenotype.
11390394 2001 Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family.
11264152 2001 Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.
10734104 2000 CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines.
10706854 2000 Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.
10642580 2000 Expression of the chemokine eotaxin and its receptor, CCR3, in human endometrium.
10477718 1999 CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.
10201960 1999 Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4.
10072545 1999 Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.
9712872 1998 Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.
9578468 1998 Delayed production of biologically active O-glycosylated forms of human eotaxin by tumor-necrosis-factor-alpha-stimulated dermal fibroblasts.
9558100 1998 Dendritic cells express multiple chemokine receptors used as coreceptors for HIV entry.
9405404 1997 Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6.
9299399 1997 Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.
9169149 1997 Genomic organization, complete sequence, and chromosomal location of the gene for human eotaxin (SCYA11), an eosinophil-specific CC chemokine.
8780731 1996 Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.
8676064 1996 Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.
8642344 1996 Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
8631813 1996 Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.
8609214 1996 Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.
8597956 1996 Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.