Tbio CCDC88C Protein Daple

Protein Summary

Description

Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway (PubMed:25062847). This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q9P219
• Q69YK1
• Q7L1M2
• Q86SX7
• Q8IYG8

Gene Name

• CCDC88C

Ensembl ID

• ENST00000389857
• ENSP00000374507
• ENSG00000015133

Symbol

• DAPLE
• KIAA1509
• HYC1
• DAPLE
• HKRP2
• SCA40
• KIAA1509

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
transcription factor binding site profile	0.84
trait	0.75
transcription factor	0.7
cell type or tissue	0.64

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Protein Daple

Protein / Enzyme Modulator / Kinase Modulator / Protein Daple

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Protein Daple

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.55   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 11   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.55   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0