| Tdark | Coiled-coil domain-containing protein 85C |
May play an important role in cortical development, especially in the maintenance of radial glia.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6685 | 3.3e-16 |
| pilocytic astrocytoma | 3086 | 4.4e-05 |
| group 4 medulloblastoma | 1875 | 5.0e-04 |
| ovarian cancer | 8491 | 9.6e-04 |
| osteosarcoma | 7933 | 8.8e-03 |
| glioblastoma | 5572 | 1.1e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 1.4e-02 |
| subependymal giant cell astrocytoma | 2287 | 2.4e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 3.6e-02 |
| spina bifida | 1064 | 4.9e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hydrocephalus | 60 | 4.194 | 2.1 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -1.177 | 8.8e-03 |
| glioblastoma | -1.100 | 1.1e-02 |
| pancreatic ductal adenocarcinoma liver m... | -1.069 | 3.6e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.100 | 1.4e-02 |
| group 4 medulloblastoma | -1.400 | 5.0e-04 |
| pilocytic astrocytoma | -1.200 | 4.4e-05 |
| subependymal giant cell astrocytoma | -1.346 | 2.4e-02 |
| psoriasis | 1.400 | 3.3e-16 |
| spina bifida | -1.283 | 4.9e-02 |
| ovarian cancer | -1.200 | 9.6e-04 |
| Accession | A6NKD9 |
| Symbols |
| PMID | Text | |
|---|---|---|
| 25649651 | Genome-wide SNP analysis identified multiple suggestive novel loci and two of them were also significant in gene-based analysis (CCDC85C and NARS2) that survived after controlling for false-discovery rate at 0.05. |
MAKPAATAAAASEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGL 1 - 70 KDVNQRLQDDNQELRELCCFLDDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRE 71 - 140 NLELKELVLLLDEERAALAATGAASGGGGGGGGAGSRSSIDSQASLSGPLSGGAPGAGARDVGDGSSTSS 141 - 210 AGSGGSPDHHHHVPPPLLPPGPHKAPDGKAGATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRQLESKVRL 211 - 280 LEGDKLLAQQAGSGEFRTLRKGFSPYHSESQLASLPPSYQDSLQNGPACPAPELPSPPSAGYSPAGQKPE 281 - 350 AVVHAMKVLEVHENLDRQLQDSCEEDLSEKEKAIVREMCNVVWRKLGDAASSKPSIRQHLSGNQFKGPL 351 - 419 //
| PMID | Year | Title | |
|---|---|---|---|
| 25649651 | 2015 | Genetic Determinants of Survival in Patientswith Alzheimer’s Disease. | |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. | |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. | |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12508121 | 2003 | The DNA sequence and analysis of human chromosome 14. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11181995 | 2001 | The sequence of the human genome. |
