Property Summary

NCBI Gene PubMed Count 12
PubMed Score 2.16
PubTator Score 4.49

Knowledge Summary


No data available


  Disease (2)

Disease Target Count Z-score Confidence
Alzheimer's disease 644 0.0 1.0



Accession Q9H6E4


  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (5)

25125657 CCDC134 promotes cell proliferation through the JAK3-STAT5 pathway.
23070808 The attenuated expression of CCDC134 promoted the activation of Erk1/2 and JNK/SAPK, but had no effect on p38 in gastric cancer.
22644376 CCDC134 might act as a novel regulator of hADA2a, and plays roles in the PCAF complex via hADA2a to affect its acetyltransferase activity and UV-induced DNA damage repair.
18187620 Knockdown of coiled-coil domain containing 134 (CCDC134) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells
18087676 These results clearly indicate that CCDC134 is a novel member of the secretory family and down-regulates the Raf-1/MEK/ERK and JNK/ SAPK pathways.

AA Sequence

EKRKEIRKGPRISRSQSEL                                                       211 - 229

Text Mined References (14)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25125657 2014 Cytokine-like molecule CCDC134 contributes to CD8? T-cell effector functions in cancer immunotherapy.
23070808 2013 CCDC134 is down-regulated in gastric cancer and its silencing promotes cell migration and invasion of GES-1 and AGS cells via the MAPK pathway.
22644376 2012 CCDC134 interacts with hADA2a and functions as a regulator of hADA2a in acetyltransferase activity, DNA damage-induced apoptosis and cell cycle arrest.
21269460 2011 Initial characterization of the human central proteome.
21123754 2011 Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
19946888 2010 Defining the membrane proteome of NK cells.
18087676 2008 CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15461802 2004 A genome annotation-driven approach to cloning the human ORFeome.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10591208 1999 The DNA sequence of human chromosome 22.