Tbio CBARP Voltage-dependent calcium channel beta subunit-associated regulatory protein

Protein Summary

Description

Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.

Uniprot Accession IDs

• Q8N350
• K7EJP2
• O43385

Gene Name

• CBARP

Ensembl ID

• ENST00000590083
• ENSP00000465260
• ENSG00000099625
• ENST00000650044
• ENSP00000497208

Symbol

• C19orf26
• DOS
• BARP
• C19orf26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.99   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 65   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.99   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0