Tbio CASP12 Inactive caspase-12

Protein Summary

Description

Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q6UXS9
• D6RBN7
• CASP-12

Gene Name

• CASP12

Ensembl ID

• ENST00000417998
• ENSP00000424963
• ENSG00000204403
• ENST00000458137
• ENSP00000421408

Symbol

• CASP-12
• CASP12P1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
chemical	0.92
disease	0.72
tissue sample	0.71
cellular component	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Inactive Caspase-12

Protein / Enzyme Modulator / Protease Inhibitor / Inactive Caspase-12

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Inactive Caspase-12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 552   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0