Tchem CARS Cysteine--tRNA ligase, cytoplasmic

Protein Summary

Description

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P49589
• Q53XI8
• Q5HYE4
• Q9HD24
• Q9HD25

Gene Name

• CARS

Ensembl ID

• ENST00000278224
• ENSP00000278224
• ENSG00000110619
• ENST00000380525
• ENSP00000369897
• ENST00000397111
• ENSP00000380300
• ENST00000612826
• ENSP00000482336
• ENSG00000278191
• ENST00000632612
• ENSP00000487923
• ENST00000633248
• ENSP00000488657

Symbol

• CARS1
• CYSRS
• MGC:11246

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
disease perturbation	0.93
transcription factor perturbation	0.91
kinase perturbation	0.84
transcription factor binding site profile	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Cysteine--trna Ligase, Cytoplasmic

Protein / Ligase / Aminoacyl-trna Synthetase / Cysteine--trna Ligase, Cytoplasmic

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Cysteine--trna Ligase, Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.12   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 217   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.12   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2