Tbio CARMIL2 Capping protein, Arp2/3 and myosin-I linker protein 2

Protein Summary

Description

Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q6F5E8
• B8X2Z3

Gene Name

• CARMIL2

Ensembl ID

• ENST00000334583
• ENSP00000334958
• ENSG00000159753
• ENST00000545661
• ENSP00000441481

Symbol

• LRRC16C
• RLTPR
• IMD58
• RLTPR
• LRRC16C
• CARMIL2b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Capping Protein, Arp2/3 And Myosin-i Linker Protein 2

Protein / Nucleic Acid Binding / Capping Protein, Arp2/3 And Myosin-i Linker Protein 2

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Capping Protein, Arp2/3 And Myosin-i Linker Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.7   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 15   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.7   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0