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Tbio
CARD18
Caspase recruitment domain-containing protein 18

Protein Summary
Description
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000530950
  • ENSP00000436691
  • ENSG00000255501

Symbol
  • ICEBERG
  • ICEBERG
  • UNQ5804
  • pseudo-ICE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.97
cell line
0.68
microRNA
0.67
chemical
0.41
phenotype
0.37


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.22   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.22   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0