| Tbio | Caprin-1 |
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 1.5e-09 |
| osteosarcoma | 7950 | 2.9e-08 |
| pituitary cancer | 1972 | 6.9e-06 |
| ovarian cancer | 8520 | 1.2e-05 |
| medulloblastoma, large-cell | 6241 | 1.3e-05 |
| acute quadriplegic myopathy | 1158 | 2.7e-05 |
| Multiple myeloma | 1332 | 3.3e-05 |
| primitive neuroectodermal tumor | 3035 | 3.4e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-04 |
| dermatomyositis | 966 | 3.4e-04 |
| nasopharyngeal carcinoma | 1058 | 7.3e-04 |
| psoriasis | 6694 | 1.4e-03 |
| Waldenstrons macroglobulinemia | 765 | 2.3e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.6e-03 |
| oligodendroglioma | 2850 | 4.9e-03 |
| ependymoma | 4679 | 6.2e-03 |
| Gaucher disease type 1 | 180 | 6.3e-03 |
| adult high grade glioma | 3801 | 6.4e-03 |
| group 3 medulloblastoma | 4104 | 6.5e-03 |
| Pick disease | 1894 | 6.6e-03 |
| lung cancer | 4740 | 1.1e-02 |
| breast carcinoma | 1638 | 1.4e-02 |
| astrocytoma | 1146 | 1.5e-02 |
| glioblastoma | 5792 | 2.1e-02 |
| Breast cancer | 3578 | 2.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.166 | 2.7e-05 |
| adult high grade glioma | -1.100 | 6.4e-03 |
| astrocytoma | 1.100 | 1.5e-02 |
| atypical teratoid / rhabdoid tumor | 1.400 | 1.7e-04 |
| Breast cancer | 4.100 | 2.7e-02 |
| breast carcinoma | 1.400 | 1.4e-02 |
| dermatomyositis | -1.100 | 3.4e-04 |
| ependymoma | 1.400 | 6.2e-03 |
| Gaucher disease type 1 | -1.100 | 6.3e-03 |
| glioblastoma | 1.300 | 2.1e-02 |
| group 3 medulloblastoma | 1.300 | 6.5e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.600 | 3.6e-03 |
| lung adenocarcinoma | 1.402 | 1.5e-09 |
| lung cancer | 1.100 | 1.1e-02 |
| medulloblastoma, large-cell | 2.300 | 1.3e-05 |
| Multiple myeloma | 2.241 | 3.3e-05 |
| nasopharyngeal carcinoma | 1.100 | 7.3e-04 |
| oligodendroglioma | 1.300 | 4.9e-03 |
| osteosarcoma | 2.479 | 2.9e-08 |
| ovarian cancer | -1.800 | 1.2e-05 |
| Pick disease | -1.100 | 6.6e-03 |
| pituitary cancer | 1.400 | 6.9e-06 |
| primitive neuroectodermal tumor | 1.100 | 3.4e-05 |
| psoriasis | 1.100 | 1.4e-03 |
| Waldenstrons macroglobulinemia | 1.633 | 2.3e-03 |
MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEK 1 - 70 KKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREE 71 - 140 AEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHA 141 - 210 SIHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPAVEDQVPEAEPEPA 211 - 280 EEYTEQSEVESTEYVNRQFMAETQFTSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQA 281 - 350 DPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPPVHSESRLAQP 351 - 420 NQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQP 421 - 490 QVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQASYNQSFSSQPHQVEQTE 491 - 560 LQQEQLQTVVGTYHGSPDQSHQVTGNHQQPPQQNTGFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPAN 561 - 630 GFRGGYDGYRPSFSNTPNSGYTQSQFSAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGM 631 - 700 PQMNTQQVN 701 - 709 //
