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  6. Calpain-8

Tbio Calpain-8

Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 20.74
PubTator Score 13.35

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Neuronal ceroid lipofuscinosis 28 4.313 2.2

Expression

  Differential Expression (15)

Disease log2 FC p
interstitial lung disease 1.600 4.2e-02
pancreatic ductal adenocarcinoma liver m... 3.607 2.2e-02
non-small cell lung cancer -1.732 1.0e-08
intraductal papillary-mucinous adenoma (... 5.000 1.1e-04
intraductal papillary-mucinous carcinoma... 4.000 6.9e-04
intraductal papillary-mucinous neoplasm ... 3.700 9.4e-03
active ulcerative colitis 1.284 4.0e-02
sarcoidosis -1.400 1.3e-02
pancreatic cancer 3.100 1.4e-06
breast carcinoma 1.300 2.0e-02
fibroadenoma 2.500 4.1e-04
interstitial cystitis -3.300 2.4e-04
lung adenocarcinoma 1.400 2.1e-03
Breast cancer -1.700 2.3e-08
psoriasis -1.100 5.9e-15

Synonym

Accession A6NHC0 B2RXL2
Symbols nCL-2

Gene

CAPN8

PANTHER Protein Class (3)

  Ortholog (1)

Species Source Disease
Mouse OMA EggNOG Inparanoid

 UniProt Keyword (11)

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 GO Function (2)

 GO Component (2)

 GO Process (2)

 Compartment GO Term (16)

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 MGI Phenotype (1)

 HCA RNA Cell Line (37)

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Pathway (2)

Protein-protein Interaction (4)

CAST   RPS3   CAPN1   FNTB  

Gene RIF (1)

PMID Text
17646163 nCL-2/calpain 8 is active without calpain regulatory subunit and oligomerizes through C2-like domains

AA Sequence 

MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQT      1 - 70
QGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFH     71 - 140
FQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGG    141 - 210
ISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEK    211 - 280
LIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSS    281 - 350
EEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW    351 - 420
RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPST    421 - 490
FEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILL    491 - 560
NEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEM    561 - 630
RTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCC    631 - 700
VLV                                                                       701 - 703
//

Text Mined References (11)

PMID Year Title
17646163 2007 Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16341674 2005 Transcriptome analysis of human gastric cancer.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11523006 2001 Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution.
11516996 2001 The calpain family and human disease.
11329013 2001 Creation of genome-wide protein expression libraries using random activation of gene expression.
8889549 1996 Generation and analysis of 280,000 human expressed sequence tags.
7690035 1993 A novel tissue-specific calpain species expressed predominantly in the stomach comprises two alternative splicing products with and without Ca(2+)-binding domain.