| Tbio | Calpain-8 |
Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 5.9e-15 |
| non-small cell lung cancer | 2890 | 1.0e-08 |
| Breast cancer | 3578 | 2.3e-08 |
| pancreatic cancer | 2398 | 1.4e-06 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.1e-04 |
| fibroadenoma | 559 | 4.1e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 6.9e-04 |
| lung adenocarcinoma | 2716 | 2.1e-03 |
| interstitial cystitis | 2312 | 6.8e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 9.4e-03 |
| sarcoidosis | 370 | 1.3e-02 |
| breast carcinoma | 1638 | 2.0e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.2e-02 |
| active ulcerative colitis | 764 | 4.0e-02 |
| interstitial lung disease | 298 | 4.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neuronal ceroid lipofuscinosis | 28 | 4.555 | 2.3 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | 1.284 | 4.0e-02 |
| Breast cancer | -1.700 | 2.3e-08 |
| breast carcinoma | 1.300 | 2.0e-02 |
| fibroadenoma | 2.500 | 4.1e-04 |
| interstitial cystitis | -2.300 | 6.8e-03 |
| interstitial lung disease | 1.600 | 4.2e-02 |
| intraductal papillary-mucinous adenoma (... | 5.000 | 1.1e-04 |
| intraductal papillary-mucinous carcinoma... | 4.000 | 6.9e-04 |
| intraductal papillary-mucinous neoplasm ... | 3.700 | 9.4e-03 |
| lung adenocarcinoma | 1.400 | 2.1e-03 |
| non-small cell lung cancer | -1.732 | 1.0e-08 |
| pancreatic cancer | 3.100 | 1.4e-06 |
| pancreatic ductal adenocarcinoma liver m... | 3.607 | 2.2e-02 |
| psoriasis | -1.100 | 5.9e-15 |
| sarcoidosis | -1.400 | 1.3e-02 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA EggNOG |
MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGYKDLGPGSPQT 1 - 70 QGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFH 71 - 140 FQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGG 141 - 210 ISEFYDLKKPPANLYQIIRKALCAGSLLGCSIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEK 211 - 280 LIRLRNPWGEVEWSGAWSDDAPEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSS 281 - 350 EEVHKWNLVLFNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW 351 - 420 RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLPPGEYLVVPST 421 - 490 FEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRLFEKLAGKDSEITANALKILL 491 - 560 NEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEFKTLWLKIQKYLEIYWETDYNHSGTIDAHEM 561 - 630 RTALRKAGFTLNSQVQQTIALRYACSKLGINFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCC 631 - 700 VLV 701 - 703 //
