Tchem CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2

Protein Summary

Description

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96RR4
• A8K7Q7
• O94883
• Q8IUG2
• Q8IUG3
• Q8N3I4
• Q8WY03
• Q8WY04
• Q8WY05
• Q8WY06
• Q96RP1
• Q96RP2
• Q96RR3
• Q9BWE9
• Q9UER3
• Q9UES2
• Q9Y5N2
• CaM-KK 2

Gene Name

• CAMKK2

Ensembl ID

• ENST00000324774
• ENSP00000312741
• ENSG00000110931
• ENST00000337174
• ENSP00000336634
• ENST00000347034
• ENSP00000321230
• ENST00000392473
• ENSP00000376265
• ENST00000392474
• ENSP00000376266
• ENST00000402834
• ENSP00000384591
• ENST00000404169
• ENSP00000384600
• ENST00000412367
• ENSP00000388368
• ENST00000446440
• ENSP00000388273
• ENST00000538733
• ENSP00000445944

Symbol

• CAMKKB
• KIAA0787
• CAMKK
• CAMKKB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
virus perturbation	0.94
kinase perturbation	0.88
protein domain	0.85
interacting protein	0.81

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Camkk Family / Meta Subfamily / Calcium/calmodulin-dependent Protein Kinase Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.49   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 369   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.49   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0