Tbio CALN1 Calcium-binding protein 8

Protein Summary

Description

Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning. This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BXU9
• J3KQA7
• CaBP8

Gene Name

• CALN1

Ensembl ID

• ENST00000329008
• ENSP00000332498
• ENSG00000183166
• ENST00000395275
• ENSP00000378690
• ENST00000395276
• ENSP00000378691
• ENST00000431984
• ENSP00000410704

Symbol

• CABP8
• CABP8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.97
PubMedID	0.67
tissue sample	0.67
phenotype	0.65
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.7   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0