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Tbio
CADM1
Cell adhesion molecule 1

Protein Summary
Description
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the sperm ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331581
  • ENSP00000329797
  • ENSG00000182985
  • ENST00000452722
  • ENSP00000395359
  • ENST00000537058
  • ENSP00000439817
  • ENST00000542447
  • ENSP00000439176

Symbol
  • IGSF4
  • IGSF4A
  • NECL2
  • SYNCAM
  • TSLC1
  • BL2
  • ST17
  • IGSF4
  • NECL2
  • RA175
  • TSLC1
  • IGSF4A
  • Necl-2
  • SYNCAM
  • sgIGSF
  • sTSLC-1
  • synCAM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
protein domain
0.97
biological term
0.88
biological process
0.85
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.23   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 573   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1050.23   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 573   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0