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Tbio
CABYR
Calcium-binding tyrosine phosphorylation-regulated protein

Protein Summary
Description
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327201
  • ENSP00000317095
  • ENSG00000154040
  • ENST00000399481
  • ENSP00000382404
  • ENST00000399496
  • ENSP00000382419
  • ENST00000399499
  • ENSP00000382421
  • ENST00000415309
  • ENSP00000399973
  • ENST00000463087
  • ENSP00000432870
  • ENST00000486759
  • ENSP00000431142
  • ENST00000621648
  • ENSP00000483621

Symbol
  • CBP86
  • FSP2
  • CT88
  • FSP2
  • CBP86
  • FSP-2
  • CABYRa
  • CABYRc
  • CABYRe
  • CABYRc/d
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
cell type or tissue
0.71
tissue sample
0.66
transcription factor
0.66
cellular component
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.12   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.12   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0