| Tclin | Carbonic anhydrase 14 |
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8491 | 2.6e-11 |
| acute quadriplegic myopathy | 1157 | 2.3e-07 |
| atypical teratoid / rhabdoid tumor | 4369 | 2.7e-07 |
| medulloblastoma, large-cell | 6234 | 8.3e-05 |
| glioblastoma | 5572 | 2.1e-03 |
| psoriasis | 6685 | 4.9e-03 |
| sonic hedgehog group medulloblastoma | 1482 | 6.0e-03 |
| primitive neuroectodermal tumor | 3031 | 4.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | 1.100 | 4.9e-03 |
| atypical teratoid / rhabdoid tumor | 4.200 | 2.7e-07 |
| glioblastoma | 1.600 | 2.1e-03 |
| sonic hedgehog group medulloblastoma | 1.800 | 6.0e-03 |
| medulloblastoma, large-cell | 1.500 | 8.3e-05 |
| primitive neuroectodermal tumor | 1.100 | 4.7e-02 |
| acute quadriplegic myopathy | -1.196 | 2.3e-07 |
| ovarian cancer | 1.400 | 2.6e-11 |
ethoxzolamide
pKi 8.60
celecoxib
pKi 6.16
imatinib
pKi 6.33
lacosamide
pKi 6.33
dichlorphenamide
pKi 6.46
acetazolamide
pIC50 6.65
nilotinib
pKi 6.65
valdecoxib
pKi 6.97
zoledronic acid
pIC50 7.04
furosemide
pKi 7.28
methazolamide
pKi 7.37
dorzolamide
pKi 7.57
brinzolamide
pKi 7.62
CHEMBL19612
pKi 6.00
CHEMBL2179308
pKi 6.03
CHEMBL370662
pIC50 6.04
CHEMBL486027
pKi 6.05
CHEMBL3291002
pIC50 6.05
CHEMBL2333590
pKi 6.07
CHEMBL2335233
pKi 6.07
CHEMBL486216
pKi 6.07
CHEMBL486026
pKi 6.07
CHEMBL2179304
pKi 6.07
CHEMBL23194
pKi 6.07
CHEMBL171476
pKi 6.07
CHEMBL359768
pKi 6.08
CHEMBL2333588
pKi 6.08
CHEMBL2333585
pKi 6.08
CHEMBL448695
pKi 6.08
CHEMBL146816
pKi 6.08
CHEMBL168526
pKi 6.08
CHEMBL165
pKi 6.08
CHEMBL1956748
pKi 6.09
| PMID | Text | |
|---|---|---|
| 24374484 | Data indicate that carbonic anhydrase isoform XIV (hCA XIV) shows high sequence identity with the other membrane-associated carbonic anhydrases (hCAs). | |
| 20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | |
| 20170095 | Results indicate that some derivatives showed potent hCA IX and hCA XIV inhibitory effects at nanomolar concentrations as well as low affinity for the ubiquitous hCA II. | |
| 17881426 | No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA. |
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYD 1 - 70 QPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYD 71 - 140 SDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYF 141 - 210 RYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQ 211 - 280 AGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA 281 - 337 //
| PMID | Year | Title | |
|---|---|---|---|
| 25056061 | 2014 | Biological insights from 108 schizophrenia-associated genetic loci. | |
| 24374484 | 2014 | The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. | |
| 24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. | |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. | |
| 20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | ||
| 20170095 | 2010 | Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies. | |
| 19206230 | 2009 | Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. | |
| 19186056 | 2009 | A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. | |
| 18618712 | 2009 | Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. | |
| 17881426 | 2008 | Familial pure proximal renal tubular acidosis--a clinical and genetic study. | |
| 17705204 | 2007 | Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. | |
| 17314045 | 2007 | Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. | |
| 17127057 | 2007 | Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. | |
| 16807956 | 2006 | Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. | |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. | |
| 16686544 | 2006 | Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 14578124 | 2003 | Gene expression for carbonic anhydrase isoenzymes in human nasal mucosa. | |
| 12975309 | 2003 | The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. | |
| 12611920 | 2003 | Human skeletal muscle and erythrocyte proteins involved in acid-base homeostasis: adaptations to chronic hypoxia. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12028451 | 2002 | Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. | |
| 11172051 | 2001 | Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. | |
| 10512682 | 1999 | Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. |
