| Tclin | Carbonic anhydrase 14 |
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.6e-11 |
| acute quadriplegic myopathy | 1158 | 2.3e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.7e-07 |
| medulloblastoma, large-cell | 6241 | 8.3e-05 |
| glioblastoma | 5792 | 2.1e-03 |
| psoriasis | 6694 | 4.9e-03 |
| primitive neuroectodermal tumor | 3035 | 4.7e-02 |
| group 3 medulloblastoma | 4104 | 4.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | -1.196 | 2.3e-07 |
| atypical teratoid / rhabdoid tumor | 4.200 | 2.7e-07 |
| glioblastoma | 1.600 | 2.1e-03 |
| group 3 medulloblastoma | -1.300 | 4.8e-02 |
| medulloblastoma, large-cell | 1.500 | 8.3e-05 |
| ovarian cancer | 1.400 | 2.6e-11 |
| primitive neuroectodermal tumor | 1.100 | 4.7e-02 |
| psoriasis | 1.100 | 4.9e-03 |
ethoxzolamide
pKi 8.60
celecoxib
pKi 6.16
imatinib
pKi 6.33
lacosamide
pKi 6.33
dichlorphenamide
pKi 6.46
acetazolamide
pIC50 6.65
nilotinib
pKi 6.65
valdecoxib
pKi 6.97
zoledronic acid
pIC50 7.04
furosemide
pKi 7.28
methazolamide
pKi 7.37
dorzolamide
pKi 7.57
brinzolamide
pKi 7.62
CHEMBL19612
pKi 6.00
CHEMBL2179308
pKi 6.03
CHEMBL370662
pIC50 6.04
CHEMBL486027
pKi 6.05
CHEMBL3291002
pIC50 6.05
CHEMBL2333590
pKi 6.07
CHEMBL2335233
pKi 6.07
CHEMBL486216
pKi 6.07
CHEMBL486026
pKi 6.07
CHEMBL2179304
pKi 6.07
CHEMBL23194
pKi 6.07
CHEMBL171476
pKi 6.07
CHEMBL359768
pKi 6.08
CHEMBL2333588
pKi 6.08
CHEMBL2333585
pKi 6.08
CHEMBL448695
pKi 6.08
CHEMBL146816
pKi 6.08
CHEMBL168526
pKi 6.08
CHEMBL165
pKi 6.08
CHEMBL1956748
pKi 6.09
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYD 1 - 70 QPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYD 71 - 140 SDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYF 141 - 210 RYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQ 211 - 280 AGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA 281 - 337 //
