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Tbio
AKR1B15
Aldo-keto reductase family 1 member B15

Protein Summary
Description
Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493). Isoform 2: No oxidoreductase activity observed with the tested substrates.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423958
  • ENSP00000397009
  • ENSG00000227471
  • ENST00000457545
  • ENSP00000389289

Symbol
  • AKR1B10L
  • AKR1R1B7
  • AKR1B10L, AK1R1B7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
protein domain
0.58
chemical
0.43
disease
0.41
biological term
0.35


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.78   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0