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Tbio
C2CD5
C2 domain-containing protein 5

Protein Summary
Description
Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333957
  • ENSP00000334229
  • ENSG00000111731
  • ENST00000396028
  • ENSP00000379345
  • ENST00000446597
  • ENSP00000388756
  • ENST00000536386
  • ENSP00000439392
  • ENST00000542676
  • ENSP00000441951
  • ENST00000545552
  • ENSP00000443204

Symbol
  • CDP138
  • KIAA0528
  • CDP138
  • KIAA0528
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor binding site profile
0.94
biological process
0.76
transcription factor perturbation
0.68
cell line
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.81   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.81   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0