Property Summary

NCBI Gene PubMed Count 15
PubMed Score 4.48
PubTator Score 3.51

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (20)

Disease log2 FC p
Rheumatoid Arthritis 1.800 3.2e-03
malignant mesothelioma -2.200 3.6e-08
glioblastoma multiforme 1.700 4.1e-14
osteosarcoma -3.054 4.9e-04
posterior fossa group A ependymoma 2.700 3.0e-10
cystic fibrosis 1.491 5.5e-05
medulloblastoma, large-cell -1.800 3.4e-04
adrenocortical carcinoma -1.320 1.9e-02
tuberculosis 2.100 8.3e-07
pancreatic ductal adenocarcinoma liver m... -1.473 5.4e-03
lung cancer -2.200 1.8e-04
adult high grade glioma 1.500 6.6e-03
atypical teratoid/rhabdoid tumor 1.600 6.0e-04
group 4 medulloblastoma -1.300 9.1e-03
pilocytic astrocytoma 2.300 3.0e-08
aldosterone-producing adenoma -1.978 7.9e-03
lung carcinoma -1.100 2.7e-22
invasive ductal carcinoma -1.200 1.0e-04
ovarian cancer -2.900 3.0e-11
pituitary cancer -2.100 5.8e-06

Gene RIF (8)

PMID Text
24667918 Microarray analysis indicates HIV-1 Tat-induced upregulation of complement component 1, r subcomponent-like (C1RL) in primary human brain microvascular endothelial cells
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20406964 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19423540 Observational study of gene-disease association. (HuGE Navigator)
19344414 Observational study of gene-disease association. (HuGE Navigator)
15385675 coexpression of the proform of Hp (proHp) and C1r-LP effected cleavage of proHp in the endoplasmic reticulum
15358180 CLSPa itself possesses little protease activity, but it plays an inhibitory role in other active protease catalytic processes

AA Sequence

MPGPRVWGKYLWRSPHSKGCPGAMWWLLLWGVLQACPTRGSVLLAQELPQQLTSPGYPEPYGKGQESSTD      1 - 70
IKAPEGFAVRLVFQDFDLEPSQDCAGDSVTISFVGSDPSQFCGQQGSPLGRPPGQREFVSSGRSLRLTFR     71 - 140
TQPSSENKTAHLHKGFLALYQTVAVNYSQPISEASRGSEAINAPGDNPAKVQNHCQEPYYQAAAAGALTC    141 - 210
ATPGTWKDRQDGEEVLQCMPVCGRPVTPIAQNQTTLGSSRAKLGNFPWQAFTSIHGRGGGALLGDRWILT    211 - 280
AAHTIYPKDSVSLRKNQSVNVFLGHTAIDEMLKLGNHPVHRVVVHPDYRQNESHNFSGDIALLELQHSIP    281 - 350
LGPNVLPVCLPDNETLYRSGLLGYVSGFGMEMGWLTTELKYSRLPVAPREACNAWLQKRQRPEVFSDNMF    351 - 420
CVGDETQRHSVCQGDSGSVYVVWDNHAHHWVATGIVSWGIGCGEGYDFYTKVLSYVDWIKGVMNGKN       421 - 487
//

Text Mined References (20)

PMID Year Title
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
20438785 2010 Polymorphisms in innate immunity genes and risk of childhood leukemia.
20406964 2010 Risk of meningioma and common variation in genes related to innate immunity.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19423540 2009 Common variation in genes related to innate immunity and risk of adult glioma.
19344414 2009 Risk of non-Hodgkin lymphoma in association with germline variation in complement genes.
19159218 2009 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
19139490 2009 A strategy for precise and large scale identification of core fucosylated glycoproteins.
16541075 2006 The finished DNA sequence of human chromosome 12.
16502470 2006 Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
15527420 2005 A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s.
15385675 2004 Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein.
15358180 2004 A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12838346 2003 Human and mouse proteases: a comparative genomic approach.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.