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Tbio
C1D
Nuclear nucleic acid-binding protein C1D

Protein Summary
Description
Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity). The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355848
  • ENSP00000348107
  • ENSG00000197223
  • ENST00000409302
  • ENSP00000386779
  • ENST00000410067
  • ENSP00000386468

Symbol
  • LRP1
  • hC1D
  • Rrp47
  • SUNCOR
  • SUN-CoR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
histone modification site profile
0.81
transcription factor binding site profile
0.8
cell type or tissue
0.64
cellular component
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0