Tbio | Protein C19orf12 |
This gene encodes a small transmembrane protein. Mutations in this gene are a cause of neurodegeneration with brain iron accumulation-4 (NBIA4), but the specific function of the encoded protein is unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Neurodegeneration with brain iron accumulation 4 | 6 | 0.0 | 5.0 |
Ovarian Neoplasms | 102 | 0.0 | 0.0 |
SPASTIC PARAPLEGIA 43, AUTOSOMAL RECESSIVE | 1 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
ovarian neoplasm | 99 |
Disease | Target Count | P-value |
---|---|---|
atypical teratoid / rhabdoid tumor | 5112 | 1.8e-09 |
glioblastoma | 5792 | 5.7e-06 |
adult high grade glioma | 3801 | 8.2e-06 |
medulloblastoma, large-cell | 6241 | 6.2e-05 |
osteosarcoma | 7950 | 6.3e-05 |
ovarian cancer | 8520 | 8.2e-05 |
breast carcinoma | 1638 | 4.3e-04 |
ductal carcinoma in situ | 1745 | 5.6e-04 |
pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.9e-03 |
astrocytic glioma | 2597 | 4.6e-03 |
invasive ductal carcinoma | 2951 | 5.6e-03 |
oligodendroglioma | 2850 | 6.2e-03 |
ependymoma | 4679 | 8.9e-03 |
fibroadenoma | 559 | 2.4e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Neurodegenerative disease | 414 | 0.0 | 4.0 |
hereditary spastic paraplegia | 318 | 0.0 | 4.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Neurodegeneration with brain iron accumulation | 20 | 6.936 | 3.5 |
Dystonia | 164 | 4.325 | 2.2 |
Optic Atrophy | 242 | 4.27 | 2.1 |
Axonal neuropathy | 27 | 4.071 | 2.0 |
alcohol-related neurodevelopmental disorder | 13 | 3.312 | 1.7 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | -1.400 | 8.2e-06 |
astrocytic glioma | -1.800 | 4.6e-03 |
atypical teratoid / rhabdoid tumor | -1.400 | 1.8e-09 |
breast carcinoma | -1.500 | 4.3e-04 |
ductal carcinoma in situ | -1.900 | 5.6e-04 |
ependymoma | -1.800 | 8.9e-03 |
fibroadenoma | -1.700 | 2.4e-02 |
glioblastoma | -1.500 | 5.7e-06 |
invasive ductal carcinoma | -1.900 | 5.6e-03 |
medulloblastoma, large-cell | -1.400 | 6.2e-05 |
oligodendroglioma | -1.900 | 6.2e-03 |
osteosarcoma | 2.486 | 6.3e-05 |
ovarian cancer | 1.500 | 8.2e-05 |
pancreatic ductal adenocarcinoma liver m... | -1.167 | 2.9e-03 |