| Tbio | Protein C19orf12 |
This gene encodes a small transmembrane protein. Mutations in this gene are a cause of neurodegeneration with brain iron accumulation-4 (NBIA4), but the specific function of the encoded protein is unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegeneration with brain iron accumulation 4 | 6 | 0.0 | 5.0 |
| Ovarian Neoplasms | 102 | 0.0 | 0.0 |
| SPASTIC PARAPLEGIA 43, AUTOSOMAL RECESSIVE | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| ovarian neoplasm | 99 |
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 1.8e-09 |
| glioblastoma | 5792 | 5.7e-06 |
| adult high grade glioma | 3801 | 8.2e-06 |
| medulloblastoma, large-cell | 6241 | 6.2e-05 |
| osteosarcoma | 7950 | 6.3e-05 |
| ovarian cancer | 8520 | 8.2e-05 |
| breast carcinoma | 1638 | 4.3e-04 |
| ductal carcinoma in situ | 1745 | 5.6e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.9e-03 |
| astrocytic glioma | 2597 | 4.6e-03 |
| invasive ductal carcinoma | 2951 | 5.6e-03 |
| oligodendroglioma | 2850 | 6.2e-03 |
| ependymoma | 4679 | 8.9e-03 |
| fibroadenoma | 559 | 2.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| hereditary spastic paraplegia | 318 | 0.0 | 4.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegeneration with brain iron accumulation | 20 | 6.936 | 3.5 |
| Dystonia | 164 | 4.325 | 2.2 |
| Optic Atrophy | 242 | 4.27 | 2.1 |
| Axonal neuropathy | 27 | 4.071 | 2.0 |
| alcohol-related neurodevelopmental disorder | 13 | 3.312 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.400 | 8.2e-06 |
| astrocytic glioma | -1.800 | 4.6e-03 |
| atypical teratoid / rhabdoid tumor | -1.400 | 1.8e-09 |
| breast carcinoma | -1.500 | 4.3e-04 |
| ductal carcinoma in situ | -1.900 | 5.6e-04 |
| ependymoma | -1.800 | 8.9e-03 |
| fibroadenoma | -1.700 | 2.4e-02 |
| glioblastoma | -1.500 | 5.7e-06 |
| invasive ductal carcinoma | -1.900 | 5.6e-03 |
| medulloblastoma, large-cell | -1.400 | 6.2e-05 |
| oligodendroglioma | -1.900 | 6.2e-03 |
| osteosarcoma | 2.486 | 6.3e-05 |
| ovarian cancer | 1.500 | 8.2e-05 |
| pancreatic ductal adenocarcinoma liver m... | -1.167 | 2.9e-03 |
