| Tdark | Protein C12orf4 |
Plays a role in mast cell degranulation.
This gene is highly conserved from nematodes to humans. In rat, the orthologous gene encodes a cytoplasmic protein that is involved in mast cell degranulation. The human gene has been implicated in autosomal recessive intellectual disability. [provided by RefSeq, Sep 2016]
This gene is highly conserved from nematodes to humans. In rat, the orthologous gene encodes a cytoplasmic protein that is involved in mast cell degranulation. The human gene has been implicated in autosomal recessive intellectual disability. [provided by RefSeq, Sep 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Pick disease | 1894 | 2.5e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 8.4e-05 |
| medulloblastoma, large-cell | 6241 | 1.7e-04 |
| ovarian cancer | 8520 | 4.7e-04 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Distal arthrogryposis | 42 | 4.093 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.200 | 8.4e-05 |
| medulloblastoma, large-cell | -1.100 | 1.7e-04 |
| ovarian cancer | 1.200 | 4.7e-04 |
| Pick disease | -1.100 | 2.5e-05 |
MKKNRERFCNREREFVYKFKVGSQCLELRVPLKFPVQENASHLHGRLMLLHSLPCFIEKDLKEALTQFIE 1 - 70 EESLSDYDRDAEASLAAVKSGEVDLHQLASTWAKAYAETTLEHARPEEPSWDEDFADVYHDLIHSPASET 71 - 140 LLNLEHNYFVSISELIGERDVELKKLRERQGIEMEKVMQELGKSLTDQDVNSLAAQHFESQQDLENKWSN 141 - 210 ELKQSTAIQKQEYQEWVIKLHQDLKNPNNSSLSEEIKVQPSQFRESVEAIGRIYEEQRKLEESFTIHLGA 211 - 280 QLKTMHNLRLLRADMLDFCKHKRNHRSGVKLHRLQTALSLYSTSLCGLVLLVDNRINSYSGIKRDFATVC 281 - 350 QECTDFHFPRIEEQLEVVQQVVLYARTQRRSKLKESLDSGNQNGGNDDKTKNAERNYLNVLPGEFYITRH 351 - 420 SNLSEIHVAFHLCVDDHVKSGNITARDPAIMGLRNILKVCCTHDITTISIPLLLVHDMSEEMTIPWCLRR 421 - 490 AELVFKCVKGFMMEMASWDGGISRTVQFLVPQSISEEMFYQLSNMLPQIFRVSSTLTLTSKH 491 - 552 //
