| Tbio | Basic leucine zipper and W2 domain-containing protein 1 |
Enhances histone H4 gene transcription but does not seem to bind DNA directly.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 3.3e-12 |
| acute quadriplegic myopathy | 1158 | 2.1e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.2e-06 |
| psoriasis | 6694 | 1.9e-06 |
| glioblastoma | 5792 | 1.7e-05 |
| ovarian cancer | 8520 | 3.8e-05 |
| adult high grade glioma | 3801 | 8.9e-05 |
| adrenocortical carcinoma | 1428 | 1.9e-04 |
| osteosarcoma | 7950 | 3.7e-04 |
| Multiple myeloma | 1332 | 4.9e-04 |
| medulloblastoma, large-cell | 6241 | 9.5e-04 |
| Astrocytoma, Pilocytic | 3081 | 1.1e-03 |
| group 4 medulloblastoma | 1855 | 1.5e-03 |
| dermatomyositis | 966 | 2.7e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 3.0e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 6.8e-03 |
| pancreatic cancer | 2398 | 9.9e-03 |
| lung cancer | 4740 | 1.3e-02 |
| astrocytic glioma | 2597 | 1.4e-02 |
| oligodendroglioma | 2850 | 1.7e-02 |
| ependymoma | 4679 | 1.9e-02 |
| Breast cancer | 3578 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Attention deficit hyperactivity disorder | 278 | 0.0 | 2.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Phlebotomus fever | 6 | 3.365 | 1.7 |
| Endometritis | 21 | 3.044 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.758 | 2.1e-07 |
| adrenocortical carcinoma | -1.583 | 1.9e-04 |
| adult high grade glioma | -1.700 | 8.9e-05 |
| astrocytic glioma | -2.400 | 1.4e-02 |
| Astrocytoma, Pilocytic | -1.200 | 1.1e-03 |
| atypical teratoid / rhabdoid tumor | -2.000 | 1.2e-06 |
| autosomal dominant Emery-Dreifuss muscul... | 1.071 | 3.0e-03 |
| Breast cancer | 2.700 | 3.8e-02 |
| dermatomyositis | 1.300 | 2.7e-03 |
| ependymoma | -2.800 | 1.9e-02 |
| glioblastoma | -1.200 | 1.7e-05 |
| group 4 medulloblastoma | -1.300 | 1.5e-03 |
| juvenile dermatomyositis | 1.401 | 3.3e-12 |
| lung cancer | 1.100 | 1.3e-02 |
| medulloblastoma, large-cell | -1.900 | 9.5e-04 |
| Multiple myeloma | 1.859 | 4.9e-04 |
| oligodendroglioma | -2.400 | 1.7e-02 |
| osteosarcoma | 1.359 | 3.7e-04 |
| ovarian cancer | -1.600 | 3.8e-05 |
| pancreatic cancer | 1.200 | 9.9e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.557 | 6.8e-03 |
| psoriasis | 1.100 | 1.9e-06 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MNNQKQQKPTLSGQRFKTRKRDEKERFDPTQFQDCIIQGLTETGTDLEAVAKFLDASGAKLDYRRYAETL 1 - 70 FDILVAGGMLAPGGTLADDMMRTDVCVFAAQEDLETMQAFAQVFNKLIRRYKYLEKGFEDEVKKLLLFLK 71 - 140 GFSESERNKLAMLTGVLLANGTLNASILNSLYNENLVKEGVSAAFAVKLFKSWINEKDINAVAASLRKVS 141 - 210 MDNRLMELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKE 211 - 280 EMKKNNIPEPVVIGIVWSSVMSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCY 281 - 350 DNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWLKNAEEESESEAEEGD 351 - 419 //
