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Tbio
BTBD7
BTB/POZ domain-containing protein 7

Protein Summary
Description
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298896
  • ENSP00000298896
  • ENSG00000011114
  • ENST00000334746
  • ENSP00000335615
  • ENST00000554565
  • ENSP00000451010
  • ENST00000613511
  • ENSP00000481899
  • ENSG00000277222
  • ENST00000613725
  • ENSP00000479193
  • ENST00000627779
  • ENSP00000486274

Symbol
  • KIAA1525
  • FUP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
microRNA
0.91
transcription factor perturbation
0.84
histone modification site profile
0.73
gene perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.36   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.36   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0