Tbio BTBD2 BTB/POZ domain-containing protein 2

Protein Summary

Description

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BX70
• O60418
• O75248
• Q4VBZ1
• Q6IAC5
• Q7Z5W0
• Q96SX8
• Q9NPS1
• Q9NX81

Gene Name

• BTBD2

Ensembl ID

• ENST00000255608
• ENSP00000255608
• ENSG00000133243

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
histone modification site profile	0.65
tissue sample	0.64
hub protein	0.63
cell line	0.59

Protein Classes

PANTHER Classes

Protein / ... / Dna Topoisomerase / Btb/poz Domain-containing Protein 2

DTO Classes

Protein / Enzyme / Isomerase / Dna Topoisomerase / Btb/poz Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.84   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.84   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0